Category: Physical Wellbeing

  • How Does The Quantity and Quality of Sleep Impact Type 1 Diabetes?

    How Does The Quantity and Quality of Sleep Impact Type 1 Diabetes?

    More Better Quality Sleep = Better Diabetes Control

    The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
    Summary: The post discusses the profound impact of sleep on managing Type 1 Diabetes. It highlights how inadequate sleep reduces insulin sensitivity, exacerbates blood sugar swings, and increases inflammation. Circadian rhythms and sleep quality are crucial, with suggestions to optimise sleep routines and environment. Strategies include managing blue light exposure and even sleeping naked for better quality sleep and health outcomes.

    Ah, the elixir of sleep!  Like the majority of people I know, I want more of it and better quality too!  I think sleep has become particularly prominent in my mind recently because I have just had the fun of crossing timezones to go on holiday.  Whilst I had a lovely time away, I am now left juggling the resulting jet lag.  I just wish I could be asleep right now!!  

    healing curing type 1 diabetes naturally

    Lack of Sleep Decrease Insulin Sensitivity in Type 1 Diabetes

    I’ve seen this happen SO many times… I’ve had a good night out with friends and stayed up pretty late.  I’ve given my night-time injection as usual and, in the morning, WHAM!  High blood sugars.  I followed all the rules but it just didn’t work.  It sucks.  So I’m fighting high blood sugars for several hours as well as feeling more-than-just-a-bit tired from my night out.  What gives?!

    It turns out that reduced insulin sensitivity after a poor night’s sleep is an expected physiological phenomenon.  For example, having just one night of four hours of sleep (between 1am and 5am) results in a decrease in insulin sensitivity of between 14-21% the next day! [1]  So, after a night out, my average total daily dose of 18.2 units would need to increase to 20.7-22.0 units!

    Similarly, one single night of no sleep (hello new parents!!) results in MORE insulin resistance than eating a high-fat diet for SIX MONTHS!! [2]  These effects also seem to be cumulative, with insulin resistance also found to be significantly increased over longer periods of time with reduced sleep. [3]

    This increased insulin requirement is, of course, not uniform.  I cannot sit down the morning-after-the-night-before and know for sure that if I increase all of my insulin levels by, say, 14% my blood sugars will be spot-on.  What is more likely to happen is that my blood sugars will swing about for most of the day as I try to guess my insulin ratios.  This will then set off a cycle of under- and over-correcting that is likely to further increase my overall insulin dose, beyond the initial 14%, for that day.

    In short, my blood glucose levels are likely to be doing this (minus the fun!)…!!
    healing curing type 1 diabetes naturally
    My Blood Sugars After a Poor Night’s Sleep

    Sleep and Inflammation

    Multiple experimental studies have highlighted the link between sleep loss and mediators of inflammation.  These mediators, known as cytokines, are secreted by cells of the immune system and are responsible for regulating levels of inflammation in the human body.

    Levels of cytokines rise in the bloodstream following sleep deprivation, as demonstrated in both sleep deprivation studies (no sleep) and also in reduced sleep studies (for example, sleeping between 25-50% of the normal sleep requirement) [4].  Whilst these studies indicate that the changes in the levels of basal inflammatory cytokines are subclinical (i.e. not dramatically huge), I believe that these shifts are still likely to contribute to the overall level of chronic inflammation in my diabetic body (see my post on allostatic load for an explanation on how I understand the mechanism by which inflammation builds up in my system).

    Circadian Rhythms Impact The Immune System

    Human bodies function on a circadian rhythm.  ‘Circadian rhythm’ is the term used to describe your body’s natural sleep-wake cycle.  During any 24-hour period, you are likely to experience times when your body requires sleep more than others.  Over time, with a regular sleeping schedule, your body’s circadian rhythm will match the sleep/wake cycle that you have and you will feel more alert and awake during your days.  Here, then, regularity in the cycle is key.

    The link between circadian rhythms and the immune system is discussed in detail in this post by the Sleep Doctor.  To summarise, he highlights how, when sleep is irregular or less than the body requires, it disrupts circadian rhythms, which as a knock-on effect on the immune system. [5]

    healing curing type 1 diabetes naturally

    Not All Sleep Is Created Equal…?

    But what time should this cycle take place?  I know I’ve certainly heard of the night owl and the morning lark (and also the joke about the alternative option of the permanently exhausted pigeon!!).  I’ve always thought of myself as a night owl.  In my ideal world, I’d like to be up late and have a good ol’ lie-in every morning, at least beyond all those horrible single-digit hours!! But is that actually good for me?

    Sleep quality changes as the night progresses.  In the first part of the night, usually from 8pm to midnight, sleep is likely to consist mostly of the deep, restorative sleep known as ‘non-REM sleep’ [6].

    In the latter part of the night, REM sleep then dominates.  It appears that the switch from mostly non-REM sleep to mostly REM sleep happens at a set time of night, in the early hours of the morning, independent of the time you went to bed.  So, for a night owl like me, I am likely to have more REM-heavy sleep, which is not as deep as non-REM sleep.  The following morning, I will not feel as refreshed as I could be. So getting to sleep earlier is crucial.

    How Can I Improve My Sleep?

    healing curing type 1 diabetes naturally

    Sleep by Nick Littlehales is a powerhouse of information on how to improve your sleep.  It is written by Nick Littlehales, a sleep expert who coaches a variety of top-class athletes and footballers, including Olympians and members of the Premier League, on how to sleep effectively.

    It appears that preparation is the key to effective sleep!  Nick Littlehales goes into great detail (in a short and easy-to-read 177 pages!) on all aspects of sleep and how to optimise it.  He includes details on:
    • The importance of pre- and post-sleep routines: how to prepare well for it and ‘recover’ from it for optimal functioning in your day.
    • The importance of a regular sleep schedule.
    • How to prepare your sleep environment (what he terms ‘the Recovery Room’!) for better quality sleep
    • How to work out the amount of sleep your body actually needs to be effective

    I have just started implementing Nick Littlehales’ recommendations into my life and I am already seeing a dramatic increase in my readiness to sleep at night and the increased level to which I feel restored in the morning.

    The Effects of Blue Light on Sleep

    healing curing type 1 diabetes naturally
    healing curing type 1 diabetes naturally

    The Effects Of Blue Light From Technology May Be Disruptive To Sleep

    Blue light is bad for sleep.  We shouldn’t be using our phones or laptops or Apple watches or iPads or anything else that emits ‘blue light’ anywhere near when we want to fall asleep.  This fact has almost become myth in today’s society and is cited widely (see here here and here for just a few examples). 

    Is it true?  Well, the jury seems to be out on this one.  Manchester University has recently demonstrated that blue light may not actually be as bad for us as today’s myth suggests [8].  In fact, the researchers from this study suggest that blue light may in fact be more beneficial for our sleep than the bright, warmer-coloured lights that are normally used in households.  

    However, in this study, the light was controlled for brightness, such that the colour of the lighting was changed from yellow to blue without affecting its brightness.  I wonder if, for electronics that tend to have bright lights with a blue tone, it is in fact the brightness, rather than the colour, that has the impact.  

    Whilst the jury may be out in the research world, I know for certain that on the evenings when I have not used any electronics – perhaps just read a book – my mind is not buzzing and I fall asleep much more quickly.  So, for me, gadgetry has to go in the last few hours of my day.

Bonus Tip: Sleep Naked!

healing curing type 1 diabetes naturally
Sleeping Naked Improves Sleep Quality

As I wandered through the literature on sleep and Type 1 Diabetes, I was surprised to find several references to the benefits of sleeping naked!

1. Sleeping Naked Promotes Sleep Quality

When you sleep naked, your body temperature lowers.  This lowered body temperature signals to your circadian rhythm that it is time for sleep and also induces deeper (non-REM) sleep.    This deep-sleep state in turn promotes longer lasting sleep since it is less likely you will be disturbed from this deep-sleep state. [9]
Better quality sleep also helps restore normal levels of the stress hormone cortisol in the body.  So, with better quality sleep, you will feel less stressed in the morning no matter how stressful your life may be in waking hours. Sleeping naked, as discussed in the previous paragraph, promotes better quality sleep and therefore helps reset your stress counter.

Reduced cortisol also reduces both inflammation and insulin resistance [10], which will decrease my overall need for insulin further.

2. Sleeping Naked Helps You Lose Weight

In a study conducted by the National Institutes of Health [11], it was found that decreased room temperature when sleeping (which can also be achieved by removing clothing!) led to an increase in brown fat and a decrease in white fat in the study participants.  Brown fat keeps your body warm by boosting the metabolism.  This increase in your metabolism lasts all day and therefore helps burn more calories!

So it looks like I’m going to be experimenting with sleeping in the buff from now on!!

healing curing type 1 diabetes naturally

References

  1. Donga, E., van Dijk, M., van Dijk, J. G., et al. (2010).  Partial Sleep Restriction Decreases Insulin Sensitivity in Type 1 Diabetes.  Diabetes Care, 33(7), 1573-1577.  [Article]
  2. Obesity Society (2015).  One Night of Poor Sleep Could Equal Six Months on a High-Fat Diet, Study Shows.  Retrieved 21st February 2020 from the World Wide Web: https://www.newswise.com/articles/one-night-of-poor-sleep-could-equal-six-months-on-a-high-fat-diet-study-shows.
  3. Buxton, O. M., Pavlova, M., Reid, E. W., et al. (2010).  Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men.  Diabetes, 59(9), 2126-2133. [Article]
  4. Mullington, J. M., Simpson, N. S., Meier-Ewert, H. K., and Haack, M. (2010).  Sleep Loss and Inflammation.  Best Pract Res Clin Endocrinol Metab, 24(5), 775-784.  [Article]
  5. Comas, M., Gordon, C. J., Oliver, B. G., et al. (2017).  A circadian based inflammatory response – implications for respiratory disease and treatment.  Sleep Science and Practice, 1(18).  [Article]
  6. Heid, M. (2017).  What’s the Best Time to Sleep?  You Asked.  Retrieved 22nd February 2020 from the World Wide Web: https://time.com/3183183/best-time-to-sleep/
  7. Littlehales, N. (2016).  Sleep.  London: Penguin Random House UK. [Link]
  8. Mouland, J. W., Martial, F., Watson, A., et al.  (2019).  Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses  to the Blue Colors Associated with Twilight.  Current Biology, 29(24), 4260-4267. [Article]
  9. Bradberry, T. (2016).  4 Reasons Sleeping Naked Makes You Healthier And Wealthier.  Retrieved 21st February 2020 from the World Wide Web: https://www.forbes.com/sites/travisbradberry/ 2016/09/13/4-reasons-sleeping-naked-makes-you-healthier-and-wealthier/#4c9f2fb969b4
  10. Holmang, A., and Bjorntorp, P. (1992).  The effects of cortisol on insulin sensitivity in muscle.  Acta Physiol Scand, 144(4), 425-431. [Article]
  11. Lee, P., Smith, S., Linderman, J., et al. (2014).  Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans.  Diabetes, 63(11), 3686-3698. [Article]
healing curing type 1 diabetes naturally
healing curing type 1 diabetes naturally

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    Picture of Natalie Leader
    Natalie Leader

    Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

    The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
    Recent Comments:
  • Daniel Darkes

    Daniel Darkes

    Miraculously Cured From Type 1 Diabetes

    Enjoyed this post?  Check out my post on ‘MORE Spontaneous Remissions From Type 1 Diabetes!’ too. But please also check out the update on Daniel Darkes here

    The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
    Summary: This article discusses the ‘miraculous’ healing of the Type 1 Diabetes veteran Daniel Darkes, who healed after having T1D for multiple years.  His diet, exercise and vitamins regime are outlined, along with thoughts about how this information can help more to heal.

    Who Is Daniel Darkes?

    Daniel Darkes is the first man (in the Western World, at least) to be cured of Type 1 Diabetes.  He has become the talk of the town in diabetes communities as people try to understand how this incurable, lifelong condition is no longer incurable or lifelong!

    Daniel Darkes was diagnosed with Type 1 Diabetes in 2010, aged 23.  He has left the British Army Grenadier Guard just four weeks before his diagnosis.  He has stated that he was discharged from the army on medical grounds but it is not clear what medical issue this was.

    Before Daniel’s body started to heal, he was originally taking 5-6 units of Novorapid for meals and 8 units of Lantus at night-time for a period of 7 years.

    Daniel Stops Taking Insulin

    In November 2016, Daniel started having episodes of recurrent hypoglycaemia at night.  Before this point, night-time hypo’s had been extremely rare for him.  Under the medical guidance of Northampton General Hospital, Daniel gradually reduced his insulin doses to try to prevent further hypoglycaemic episodes.  However, no matter how little he gave, he continued to hypo.  Eventually, it got to the point that Daniel’s consultant made the decision to stop insulin altogether.

    The Impossible Becomes Possible

    When I think about Miracle Dan (as Daniel Darkes has been named by his friends), I am reminded of the story of the four-minute mile.  On May 6th 1954, Roger Bannister was the first man to run a mile in under four minutes.  Athletes had tried since 1886 to break this barrier and none had succeeded.  It was therefore assumed that this was a feat beyond human capability, something that the human body just could not do.  However, once Bannister broke this barrier, many others followed.  The impossible had become possible.  Once they saw it could be done, many others did it too. 

    For me, Daniel Darkes is the Roger Bannister of Type 1 Diabetes.  He has broken the barrier and shown that this ‘incurable’ condition is curable.  We now know the impossible is possible.

    healing curing type 1 diabetes naturally

    Reactions To Daniel Darkes’ Cure

    The medical and diabetic communities have not been wholly receptive to the news of Daniel Darkes’ cure.  For example, Live Science wrote a piece highlighting what they believed to be inconsistencies in Daniel Darkes’ story.  Firstly, they questioned the validity of his original Type 1 Diabetes diagnosis.  They also used Daniel Darkes’ refusal to provide his medical records (actually, it was his NHS trust that refused due to patient confidently laws in the UK), plus the absence of a published medical case study, to infer that this may be some kind of hoax.

    As I ponder this reaction, I am reminded of quote by Arthur Schopenhaueur:

    healing curing type 1 diabetes naturally

    It appears to me that, unfortunately, Daniel Darkes’ healing is encountering the first two stages of truth – ridicule and violent opposition.  Change in the medical world takes time.

    healing curing type 1 diabetes naturally

    Daniel Darkes has stumbled across the way to heal Type 1 Diabetes.  So, whilst the medical community is adjusting its lens to the new reality, I’d like to get on with actually learning as much as I can about how he achieved it!

    What Do We Know About Daniel Darkes’ Miracle Cure?

    Daniel’s Diet

    Daniel appears to have a very healthy diet.  He runs a lot (see below) and therefore takes care of his nutrition for this.  When not running, his diet tends to consist of a lot of fish, chicken and vegetables, basically pretty low-carb.  He might eat fruits, nuts and crackers for lunch.  He doesn’t eat sweet stuff, chocolate or have sugar in his tea.  But, before I panic about such a restrictive diet, he does admit to also having the occasional beer or sweet treat or takeaway at weekends!!  

    On days when Daniel is running a long run, he will increase his carbohydrate intake by adding in a serving of rice, pasta or sweet potato for dinner and/or porridge for lunch.  He will also have gels or sweets on the runs to top up his blood sugars, if needed. 

    healing curing type 1 diabetes naturally
    healing curing type 1 diabetes naturally
    healing curing type 1 diabetes naturally

    Foodstuffs Found In Daniel Darkes’ Diet

    Daniel’s Vitamins and Supplements

    Daniel has said that he takes the following vitamins and supplements on a daily basis:

    Daniel’s Exercise Routine

    Daniel is a long-distance runner.  He regularly runs marathons and ultra-marathons.  He is dedicated to his fitness.  He tends to run 15-30 miles a couple of times a week and then does a longer run at the weekend.

    healing curing type 1 diabetes naturally

    Enjoyed this post?  Check out my post on ‘MORE Spontaneous Remissions From Type 1 Diabetes!’ too.

    What The Experts Think

    Daniel Darkes says that the experts on his case have identified a rare gene that he possesses that is acting as a back-up immune system by recharging the pancreatic cells to produce insulin.

    What I Think

    Issues With The Experts’ Explanation

    Hang on a minute!  The old-school way of looking at diabetes said that the beta cells in the pancreas – the ones that produce the insulin – have been obliterated by our misfiring immune systems.  And now they can recharge?!  This fits in with what I have so far argued on my blog – that this theory of ‘burnt out beta cells’ has little scientific support and has actually been replaced with the finding that beta cells do still exist in the pancreas and can, under the right environmental conditions, start producing insulin again.  

    I also have an issue with this ‘rare gene’ hypothesis… My issue sits in the findings of epigenetics.  Epigenetics argues that individuals are not necessarily destined to suffer (or enjoy!) the blueprints of their inherited DNA sequences.  In other words, you may receive programming, via your DNA, from one or other parent but that does not mean that you are destined to have that gene expressed and acted out in your life.  Instead, genes have been found to be affected throughout a person’s lifespan by a range of factors, including diet, exposure to pollutants and even emotions.  it is the epigenetics, influenced by this diverse range of factors, that determine whether genes are turned on or off.  Why this is relevant to Daniel Darkes is because this ‘rare gene’ may have in fact been created during his healing process, as a result of epigenetics.  Equally, this may be a gene that we all possess, but as yet Daniel is the only one who has found a way to get this gene turned on and working.

    Western Medicine Has Not Undertaken A Holistic Investigation

    I struggle with the findings, and lack of findings, that I have so far heard about Daniel’s case.  So far, all investigations seem to have proceeded down only the expected avenues… Inquiries into diet, exercise, supplements, blood sugar readings and so on.  In other words, all focus has been on medical questions, which treat the body as a machine with a broken component (see my post on Descartes for more information).  As such, I believe the lens of inquiry is too narrow.  

    We Also Need To Be Asking Daniel About…

    Nobody is asking Daniel about the wider healing that he may have undertaken.  As I highlighted in my post on neuropeptides, the brain is highly interrelated with the body via emotions.  Has anybody asked Daniel what his emotional journey has been like over the time his healing took place?  Were there any shifts in his emotional outlook, for example?  Candace Pert would argue that emotional healing is as likely to improve health as much as any medical intervention.

    I also wonder about his running.  The experts have said that his long-distance running has somehow ‘shocked’ his immune system, via this rare gene, to start working again.  How do they know that it wasn’t some other factor to do with running that would have helped?  For example, Daniel is likely to have maintained good hydration to be able to run.  He is also likely to have spent a lot of time outdoors in nature, which in itself can be very healing.  The added benefit of sunshine on the body, and the resultant levels of vitamin D, are also worth questioning.  Perhaps it was any one of these factors, or the combination of all of them, rather than the running itself, that led to his healing. 

    I have also heard about the great benefits of fasting and its ability to regenerate the immune system (although fasting can come with great risks for diabetics).  Did Daniel have any intentional or unintentional periods of fasting, perhaps due to long runs or periods of illness, which may have instead been responsible for kickstarting his immune system?

    I have seen no evidence that the medical teams are asking these kinds of questions.  If they are not, they are not controlling for extraneous variables in their research design and, as such, according to the rules of scientific research, their method and findings are confounded.  No firm conclusions can be drawn.

    Dr Kelly Turner

    As this post comes to an end, I am thinking back to Dr Kelly Turner’s work on spontaneous remissions of cancer.  Kelly outlined how healing is based on a range of factors, only two of which were body-based (those of ‘radically changing your diet’ and ‘herbs and supplements’).  By asking Daniel only about the body-based activities and treatments he had, we are missing out on finding out about the majority of his healing journey.

    Dr Kelly Turner also discussed how valuable information about healing can be gained from asking the patient themselves what they believe healed them.  Daniel Darkes thinks his healing resulted from the combination of his running and his diet, which is high in zinc, nuts, oily fish and vegetables. 

    I intend to use Daniel Darkes’ route to health as a roadmap for my own healing.  However, I am hoping that I won’t need to achieve the fitness of an ultra-marathon runner to heal my Type 1 Diabetes…  I dearly hope that my unique path to healing may  not require such a high level of physical exertion for the same results!!  Let’s wait and see.

    Enjoyed this post?  Check out my post on ‘MORE Spontaneous Remissions From Type 1 Diabetes!’ too.

    healing curing type 1 diabetes naturally
    healing curing type 1 diabetes naturally

    GET HEALINGT1D’S FUTURE ARTICLES IN YOUR INBOX!

    Get the latest musings and findings straight to your email inbox.

      Picture of Natalie Leader
      Natalie Leader

      Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

      The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
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    • Allostatic Load

      Allostatic Load

      Re-Understanding The Development Of Type 1 Diabetes As Progression Along A Continuum

      The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
      healing curing type 1 diabetes naturally
      Stress Results In A Release of Hormones To Counteract Environmental Threats

      Summary: This article provides a conceptual framework for understanding the path to healing Type 1 Diabetes.  Currently, the condition is seen as something that has ‘switched on’ in our bodies and remain there permanently.  Perhaps instead we can use the concept of an ‘allostatic load’ to see T1D as a status that arrives when the environment of the cells has tipped towards too much toxicity or they are under too much challenge from areas such as the diet, feelings of the individual, amount of exercise, and all other life experiences.  Using this concept, the focus then becomes about how to tilt that seesaw back towards health and healing.

      Stress impacts the human body.  We all know this!  When stressed, our bodies produce a series of hormones to equip the individual to deal with a perceived or actual threat in the environment.

      Hormones

      There are two main types of hormones that are produced as a result of stress: glucocorticoids and catecholamines.

      Glucocorticoids:

      These are also known by the name glucocorticosteroids (which gives an impressive Scrabble score of 28 points!).  These are part of the immune system feedback loop, which helps maintain homeostasis in the human body.  One well-known glucocorticoid is cortisol, the ‘stress hormone’.  Glucocorticoids have many functions, including:

      1. An Ability To Stop Inflammation In The Body:

      It does this by suppressing the release of molecules called proteins, which are used in the inflammatory process [1].  Glucocorticoids are therefore great at stopping the damage done by overactive immune system disorders, such as type 1 diabetes. 

      2. A Role In Regulation Of Glucose Metabolism:

      Glucocorticoids encourage glucose production in the liver and also prevent insulin from working effectively to uptake glucose [2].  Glucocorticoids also affect pancreatic alpha and beta cell functioning [3].  This influences the amount of glucagon and insulin released into the bloodstream.  The goal of glucocorticoids is to keep glucose in the bloodstream so that the brain, during times of stress, can work at maximum capacity [2]. 

      Catecholamines:

      Catecholamines (a mere 23 points in Scrabble!) are another type of hormone released during stressful life events.  They are produced by my adrenal glands, which are located just above my kidneys.  Examples of catecholamines are dopamine, norepinephrine and epinephrine (aka adrenalin).  These hormones are sent into my bloodstream every time I get physically or emotionally stressed.  Like glucocorticoids, catecholamines raise blood sugar levels, as well as heart rate, blood pressure and increased arousal of the sympathetic nervous system.

      What Is Allostasis?

      Both of these hormones, glucocorticoids and catecholamines, have beneficial short-term effects in the body.  They prepare the body for a fight-or-flight response in times of stress or threat to life, for example.  This process of adjusting the body, through physiological and/or behavioural changes, is known as ‘allostasis’ [4].

      Allostatic Load

      However, in the long-term, the process of allostasis can become disadvantageous and even burdensome on the body.  Such a burden is known as the ‘allostatic load’ [4].  The higher my allostatic load, the more burden my body is carrying, in terms of raised blood glucose levels, higher stress levels, increased inflammation and so on.  For example, chronic stress can lead to high levels of the glucocorticoid ‘cortisol’ (yes, that’s right, the ‘stress hormone’ as it’s known!).  Chronically elevated cortisol levels can lead to:

        • Anxiety
        • Depression
        • Digestive problems
        • Sleep problems
        • Weight gain
        • Issues with memory [5]

      How Is Allostatic Load Relevant To T1D?

      Allostatic load is the burden the body has as a result of (ongoing) environmental stressors.  It takes a toll on the system and, over time, creates a whole range of health issues [6]. 

      Both the sympathetic nervous system and the neuroendocrine system (that’s the system that influences both hormones, like insulin, and neurons, including those in the brain) play central roles in the concept of ‘allostatic load’ [7].  In other words, chronic stress reduces insulin production and affects brain functioning.  A lack of insulin production results in Type 1 (or Type 2 or MODY) Diabetes.

      Dopamine is an example of a catecholamine.  Insulin has been found to be strongly associated with the ‘pleasure’ centre of the brain, the striatal region, where dopamine is produced. [8].  The more insulin there is in the bloodstream, the more dopamine is released from the striatal region.  Dopamine is a feel-good chemical.  In a Type 1 Diabetic, when blood sugar levels are too high, the resulting mood is likely to not be a very fun one… Oh, I know that grumpiness of high blood sugars!!   In a non-diabetic, I would anticipate that the reverse must be true… The more joy they experience, the more they are able to produce insulin. 

      healing curing type 1 diabetes naturally

      In my post on Descartes and the Mind-Body Split in Western Medicine, I touched upon the research that highlights a connection between stressful life events and subsequently developing T1D.  As discussed, chronic stress releases glucocorticoids and catecholamines that shut down insulin production and increase glucose concentrations in the blood.  So perhaps the reverse can be true…?  If I can reduce my allostatic load, it gives my system more of a chance of increasing (starting!) insulin production.  It makes my bodily environment more welcoming to growing some new beta cells (as discussed in my post ‘What is Type 1 Diabetes?’).

      My Take-Home Message

      For me, the concept of an allostatic load is something to hold going forward.  Instead of understanding my beta cells as being burnt out or broken, I am seeing them as being in an environment that stops them from switching back on.  

      The environmental conditions in my body are fuelled by all the factors that contribute to my allostatic load.  These include my diet, my feelings of helplessness, my exercise regime, my response to my life experience, the amount of daily stress I carry with me, and so on.
      In other words, Type 1 Diabetes is a multifaceted disorder.  Thus, each one of these things that I can improve or eliminate, the smaller the burden of my allostatic load will be.  I am therefore looking to improve all areas of my life that I feel may contribute to my allostatic load and thus fundamentally reduce it.  I will watch to see what happens to my blood sugar levels (and pancreatic function) from there!

      Summary

      • Stress produces two types of hormones in the body: glucocorticoids and catecholamines.
      • Glucocorticoids stop inflammation in the body and increase and/or maintain blood glucose levels, ready for the individual to respond to threat.
      • Catecholamines raise blood sugar levels, as well as heart rate, blood pressure and arousal in the sympathetic nervous system.
      • Allostatic load is a measure of the amount of cumulative stress placed on a system due to adjustments the body makes to maintain homeostasis.
      • Allostatic load can be used conceptually to understand T1D. Healing from T1D, using this approach, requires an overall reduction on stressors in the system that can contribute to a high allostatic load.

      After-Thought…

      Writing this post has also given me some food for thought on a related point…  The dominant model for understanding Type 1 Diabetes is the Eisenbarth model (see my post on ‘What is Type 1 Diabetes?’ for more info on this).  If researchers are using this model as their way of understanding T1D, they are going to assume that the beta cells in the pancreas are burnt out.  Therefore, measuring the C-peptide, for example, once only is a sufficient indicator of the amount of insulin-producing cells left in that individual’s pancreas. 

      However, if that model is flawed and insulin production fluctuates with allostatic load over the course of a day, a week or a month, then measuring C-peptide would only indicate the amount of functioning beta cells at that moment in time.  The C-peptide test is most often done, if at all, in the early days after diagnosis of T1D.  At such a stressful time of life, when your allostatic load is likely to be huge, a low C-peptide level would almost be guaranteed.  This would give an explanation for the ‘honeymoon effect’ of a lot of T1Ds since, after diagnosis, they are often looked after mentally, physically and emotionally by those around them.

      References:

      1. Barnes, P. J. (1998). Anti-inflammatory actions of glucocorticoids: molecular mechanisms.  Clinical Science (London), 94(6), 557-572.
      2. Kuo, T., McQueen, A., Chen, T. C., and Wang, J. C. (2015). Regulation of Glucose Homeostasis by Glucocorticoids.  Advances in Experimental Medicine and Biology, 872, 99-126.
      3. Rafacho, A., Goncalves-Neto, L. M., Santos-Silva, J. C., Alonso-Magdalena, P., et al (2014).  Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats.PLoS One, 9(4), e93531.
      4. McEwen, B. S. (2000). Allostasis and Allostatic Load: Implications for Neuropsychopharmacology.  Neuropsychopharmacology, 22, 108-124.
      5. Talbott, S. M. (2007). The Cortisol Connection: Why Stress Makes You Fat and Ruins Your Health – And What You Can Do About It.  Nashville, TN: Hunter House.
      6. McEwen, B. S. (2000). The Biological Basis for Mind Body Interactions.  Progress in Brain Research, Vol 122.  New York: Elsevier.
      7. Kiecolt-Glaser, J. K., McGuire, L., Robles, T., and Glaser, R. (2002).  Psychoneuroimmunology: Psychological Influences on Immune Function and Health.  Journal of Consulting and Clinical Psychology, 70(3), 537-547.
      8. Stouffer, M. A., Woods, C. A., Patel, J. C., Lee, C. R. et al. (2015). Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals rewards.  Nature Communications, 6, 8543.
      healing curing type 1 diabetes naturally
      healing curing type 1 diabetes naturally

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        Natalie Leader

        Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

        The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
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      • The SHOCKING Truth About Insulin!

        The SHOCKING Truth About Insulin!

        Hormones, Neuropeptides and… Acid!

        The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
        healing curing type 1 diabetes naturally

        Summary: This article discusses outlines the role of insulin in diabetes, highlighting how it is a hormone that acts on the permeability of cells.  The discovery of insulin by Banting and Best is outlined, followed  by a discussion of the modern-day insulins that are available.  A consideration of the synthetic components contained within  insulin are discussed, along with its properties of being both a hormone and a neuropeptide.

        Ah, the elixir! The magic potent drug that keeps me alive and well. What would I do without you?!

        Now, for me, it’s funny sitting here writing this post… For decades, I have (mostly!) diligently put insulin into my system. This has been via syringes (originally ones that were sterilised by boiling them in a saucepan!!) then insulin pen devices then an insulin pump and now syringes again. All those units of insulin, all those vials, all those bottles… But I actually know so little about this wonder drug! Is it even a drug?!

        What Is Insulin?

        So, to answer my first question… No, insulin is not a drug (until it is put into bottles and sold by pharmaceutical giants, anyway!).  A plethora of books, articles and webpages kindly inform me that insulin is a hormone [1, 2, 3].

        What Are Hormones?

        Hormones are a type of molecule in the human body that are transported around the body by the circulatory system.  They are taken to places in the body to stimulate specific cells or tissues to produce a predetermined action.  The hormone insulin is produced in the pancreas in the beta cells.  Insulin is then dispatched into the bloodstream to act on the glucose molecules found there.  Insulin works by increasing the permeability of the cells in the human body.  With increased permeability, each cell is able to absorb more glucose from the bloodstream, resulting in lower amounts of glucose molecules in the blood [4].

        A Brief History Of Insulin

        I have to admit that I’m not a great fan of learning about the past.  I had a really boring history teacher when I was at school who, I think, successfully put me off history for the rest of my adult life.  Saying that, I don’t mind a quick delve into the textbooks of the past when I feel there’s something to be gained.  This is true for insulin.

        Insulin was not discovered until 1922.  Prior to its discovery, the life expectancy of children and young adults with type 1 diabetes was very poor, with deteriorating health and death always imminent.  My mother’s great-grandmother was one of the early ones to suffer this fate, dying when she was just 19 years old.

        Thankfully, advances have been made.  In 1922, insulin was discovered by Frederick Banting and Charles Best, under the directorship of John Macleod, following their investigations into the pancreatic function of dogs [5].  They siphoned off a pancreatic extract from the dogs’ pancreases (what we now know to be insulin) and found that the dogs developed diabetes.  By re-injecting this pancreatic extract back into the dogs, the dogs’ blood sugars were lowered.

        C. H. Best and F. G. Banting ca. 1924.png
        Charles H. Best and Banting, c. 1924.

        The insulin that was extracted from the dogs’ pancreases in these experiments was not purified.  Therefore, when it was injected for the first time into a human being, that of a fourteen year old boy, the lack of purification resulted in a sterile abscess and little effect on the blood sugar levels [6].  Banting and Best, with the help of their biochemist colleague J. B. Collip, purified the pancreatic extract, resulting in the first medically viable insulin [7].  In 1923, Banting and Macleod were awarded the Nobel Prize for their discovery of insulin.

        Over the following decades, procedures for extracting insulin were refined. Eli Lilly began producing insulin from animal pancreases. He found that the insulin from dead pigs and cows was particularly suited to humans.

        In 1982, ‘human’ insulin was produced for the first time. Human insulin is manufactured from genetically engineering the bacterium of yeast cells to produce insulin.

        On the market today, there are over 40 different types of insulin available to the diabetic consumer. The vast majority of diabetics use human insulin. However, natural animal insulins, which have no synthetic properties, are still available in some countries, including my home country of the UK. I feel this fact is important to know when considering healing from Type 1 Diabetes. I wish to make my body as healthy as I can, which I believe involves removing as many extraneous toxins as possible.

        Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting…

        Today, we are blessed to have so many different types of insulin available to us. Whatever our bodily responses to food, exercise and generally just staying alive(!), there is an insulin to match it.

        i) Rapid-acting
        ii) Short-acting
        iii) Intermediate-acting
        iv) Long-acting
        v) Pre-mixed

        Each of these types of insulin have different profiles for how long it takes them to start to work and how long they remain effective in the human body. Rapid-acting insulins, such as Novorapid (also known as Novolog), Humalog and Apidra, all start working in 10-20 minutes and last for two and half hours to five hours (although every human body is different so I only ever take these as rough guides until I’ve seen what they do to me in practice!).

        Short-acting insulin tends to have a slower onset and duration than the rapid-acting insulins. Actrapid (also known as Regular insulin) is the most well-known type of insulin in this this group.

        NPH is an intermediate-acting insulin, so-called because it takes 1-2 hours to start to work but then last in the system for about half a day.

        In the long-acting group is insulin glargine (the most commonly known ones being Lantus and Toujeo), insulin determir (known as Levemir) and Insulin degludec (known as Tresiba). These have a much longer onset time, somewhere between one to two hours depending on the specific type, but last up to 24 hours or longer.

        The last group are the pre-mixed insulins, which consist of both short-acting and long-acting insulins.Some examples are Humulin 70/30 and Novolog 70/30, both of which take 30 minutes to onset and last up to 24 hours.

        The Lesser Known ‘Amylin’

        As I was reading up on insulin production, I found that the insulin-producing beta cells in the pancreas don’t just produce insulin. They also produce another hormone… Amylin.

        Amylin is the hormone that helps insulin to attain optimal blood glucose levels after meals.  It has many roles…

        1. It slows the digestive process, which means that carbohydrates take longer to enter the bloodstream. This results in smaller blood sugar spikes after meals.

        2. Prevents glucagon being secreted from the pancreas. Glucagon is a hormone that is responsible for raising blood sugar levels. That means, for me as a type 1 diabetic, I have the added joy of MORE glucagon being released when I eat a meal. So my poor body has to cope with even more free-floating glucose in my bloodstream. Consequently, I have to take more insulin; some to cover the meal itself and some to cover this additional glucagon spike.

        3. Amylin increases feelings of satiety. Increasing satiety would dissuade me from reaching for that third second piece of cake after dinner or that lovely chocolate cookie between meals. But, nope, I don’t have amylin. So THAT is why I feel like I… am… always… hungry!!

        There is a product on the market called Symlin, which is synthetic amylin that can be used to counteract the lack of amylin in your system.

        However, for me, that is not really a choice I wish to make. I am striving to get my body back to as natural a setting as possible and focusing on getting my body to regenerate itself as much as possible. But just knowing that there is a reason why I don’t ever feel satisfied at the end of a meal (no matter how full my belly is!) lets me know that that is okay. I can make peace with that.

        My Experience of Insulin

        I have been on a range of insulins over the years. When I was first diagnosed, I had two injections a day of mixed Actrapid and Monotard (an old long-acting insulin). This continued until I was eight or nine years old, when I was switched to Novorapid three times per day with meals and Protaphane at bedtime. I have played about with different types since then, including taking purely Novorapid through an insulin pump for a five-year period. Currently, my insulin regime tends to take one of two approaches:

        When eating a carbohydrate-rich diet (50-100 grams per day), I find that Novorapid at meal times plus one large-ish dose of Lantus at bedtime is the most effective.

        When eating lower amounts of carbohydrates (usually 30-40 grams per day), I require a different regime. I find that Actrapid is more effective for meals (since the protein content of my meals gives the larger blood sugar hit and this hits in later than simple carbohydrates) and two doses of Lantus (at night and in the morning) gives me better stability in my daily blood sugars.

        Always Read The Label…

        Now this was a bit of a shocker for me. I had always assumed that the insulin I was putting into my body on a more-than-daily basis was just that… Insulin. Well, it turns out that I have been duping myself.  I decided to read the package leaflet for each insulin to discover what I was really putting into my body.

        Lantus:

        At the moment, I use Lantus (insulin glargine) from 3 mL pre-filled cartridges. These contain insulin glargine, plus the following inactive ingredients:
      • Zinc chloride
      • Metacresol
      • Glycerol
      • Sodium hydroxide
      • Hydrochloric acid
      • Water for injections
      • Novorapid:

        I use Novorapid (Novolog) vials for my mealtime injections. They contain:
      • Glycerol
      • Phenol
      • Metacresol
      • Zinc chloride
      • Disodium phosphate dihydrate
      • Sodium chloride
      • Hydrochloric acid
      • Sodium hydroxide
      • Water for injections
      • I have to admit that, whilst I’m deeply grateful for my insulins and their ability to keep me alive and well, I’m really disappointed to see how many additional chemicals I am putting into my body on a daily basis.  This makes me think more deeply about using animal insulin rather than synthetic insulin.  I think I need to investigate that idea further.

        Insulin And The Brain

        “You what?! What do you mean ‘insulin and the brain’? They have absolutely nothing to do with each other!” was my first thought on this topic.  After all, I’ve never had discussions about my brain with my diabetologist.  Well, it turns out that maybe I should…!

        Early research believed that insulin purely existed in the pancreas and in the bloodstream. It was simply a hormone.

        However, recent research is showing that insulin is in fact highly involved with the brain. It appears that insulin has several roles in the brain and is involved in multiple neural pathways [10].

        Insulin was first found in the brain in the late 1970s by Jana Havrankova and colleagues [11]. This early research was conducted on rat brains but insulin has similarly been detected in human brains [12].

        For this reason, researchers of today are now choosing to refer to insulin as a ‘neuropeptide’.

        What Are Neuropeptides?

        Peptides are protein-like molecules that are used by nerve cells (called neurons) to communicate with each other. They are made up of a string of amino acids and are usually shorter in length than proteins.

        Neuropeptides are a specific type of peptide that are released from neurons (in the brain and central nervous system) and act on neighbouring neurons.

        A hotly debated area in the world of neuropeptides and insulin production is whether or not insulin is made in the brain [13].

        Whilst there appears to be no clear conclusion on this matter as yet [10], the latest research is strongly indicating that there is in fact insulin being produced by the brain [14].

        Is Insulin A Neuropeptide Or A Hormone?

        It turns out that insulin is BOTH… A hormone and a neuropeptide (see my post here for more on this topic).  Insulin is produced in the pancreas by beta cells (in non-diabetics) and travels through the bloodstream to act on glucose molecules.  This makes it a peptide hormone.  However, as discussed above, some preliminary studies are indicating that it is also produced in the brain and acts on neighbouring brain regions.This firmly places insulin in the neuropeptide camp too.

        Why Does It Matter If Insulin Is A Neuropeptide Or A Hormone?

        Neuropeptides are mainly brain-focused.  Hormones are mainly body-focused.  Insulin is both a hormone and a neuropeptide.  It has actions in both the brain and the body.  Type 1 Diabetes results from a lack of insulin.  So has the insulin production been disrupted in the brain or the body or both?  

        For me, it seems obvious that Type 1 Diabetes cannot be just a disorder of the pancreas.  It is not a purely physical disease with a purely physical origin.  If it acts in both the brain and the body and is produced in both the brain and the body, then both the brain and the body must go wrong at the time of the onset of T1D.  Going forwards, this further underlines for me how my healing from T1D needs to involve both my mind and my body.  Both of them need to be healed, not either in isolation from the other.

        Summary

        • Insulin is a hormone that T1Ds require to regulate blood glucose control.
        • Insulin today comes in two types: synthetic ‘human’ insulins and natural animal insulins.
        • Human insulins contain, as well as insulin, multiple additional ingredients including zinc chloride, metacresol, glycerol, sodium hydroxide and hydrochloric acid.
        • Insulin acts on both the pancreas and the brain.  It is therefore both a hormone and a neuropeptide.
        • T1D can therefore be understood as being associated to both the mind and the body.

        References

        1. Holt, R. I. G., and Hanley, N. A. (2012). Essential Endocrinology and Diabetes.  Chichester, UK and Hoboken, NJ: Wiley-Blackwell Publishers.
        2. Scheiner, G. (2011). Think Like A Pancreas: A Practical Guide to Managing Diabetes With Insulin (2nd ed.).  Cambridge, MA: Da Capo Press.
        3. Neal, M. J. (2012). Medical Pharmacology at a Glance (7th ed.).  West Sussex, UK: John Wiley and Sons.
        4. Stryer L (1995). Biochemistry (4th ed.). New York: W.H. Freeman and Company.
        5. Banting, F. G., Best, C. H., Collip, J. B., Campbell, W. R., and Fletcher, A. A. (1922). Pancreatic extracts in the treatment of diabetes mellitus.  Preliminary Report.  Canadian Medical Association Journal, 12, 141-146.
        6. Quianzon, C. C., and Cheikh, I. (2012). History of Insulin.  Journal of Community Hospital Internal Medicine Perspectives, 2(2), 10.
        7. Bliss M. (1993). The History of Insulin. Diabetes Care, 16(3), S4-7.
        8. https://www.iddt.org/diabetic-commonsense/the-great-debate-natural-animal-or-artificial-human-insulin
        9. https://www.sciencedaily.com/releases/2015/10/151027074802.htm
        10. Gray, S. M., Meijer, R. I., Barrett, E. J. (2014). Insulin Regulates Brain Function, but How Does It Get There? Diabetes, 63(12): 3992-3997.
        11. Havrankova J., Schmechel, D., Roth, J., Brownstein, M. (1978).  Identification of insulin in rat brain. Proc National Academy of Science U S A, 75(11), 5737–4110.
        12. Dorn, A., Bernstein, H. G., Rinne, A., Ziegler, M., Hahn, H. J., Ansorge, S. (1983). Insulin and glucagonlike peptides in the brain. Anatomical Record, 207(1), 69–77.
        13. Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., and Ruiz-Albusac, J. M. (2014). Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease.  Frontiers in Endocrinology, 5, 161-182. 
        14. Molnár,  G., Faragó,  N., Kocsis,  A. K., et al. (2014). GABAergic neurogliaform cells represent local sources of insulin in the cerebral cortex.  Journal of Neuroscience, 34, 1133–1137.
        healing curing type 1 diabetes naturally

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          Natalie Leader

          Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

          The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
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        • What Is Type 1 Diabetes REALLY?

          What Is Type 1 Diabetes REALLY?

          The “Beta Cell Burnout Theory” May Not Be True
          The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
          curing healing type 1 diabetes naturally

          Summary: The Eisenbarth model explains Type 1 Diabetes (T1D) as an autoimmune disease where the immune system targets and eliminates pancreatic beta cells, cells that are crucial for insulin production. However, recent research offers hope for treatment advancements and cure.  Research has highlighted the potential for beta cell preservation and regeneration, including findings on delta cell transformation and the presence of dormant and baby beta cells in the pancreas.

          After 38 years with diabetes, I felt pretty sure that I was the Mastermind champion on Type 1 Diabetes (T1D)!

          I knew that my pancreas had stopped functioning.  I knew that I needed to take regular insulin injections (or insulin pump infusions) to replace the lost insulin that my pancreas no longer produces.

          I knew that my pancreas was defunct. Irreparable. Beyond salvation.  Dead as a dodo.

          Life with T1D

          T1D management can be tricky and, at times, onerous.  I maintain my T1D through testing my blood sugar levels up to ten times per day.

          I inject insulin at each meal and at bedtime (see my ‘Insulin‘ post for further exploration on this topic).

          I inject varying amounts of insulin for each meal.  The amount depends on the carbohydrates on my plate (or, more accurately, in my stomach!!).

          Insulin dosing is a fine art.  Too much, I hypo (hypoglycaemia).  I become listless, confused and sometimes uncooperative.  Too little insulin, my blood sugars run too high (‘hyperglycaemia’).  I become irritable, anxious and sometimes mean.

          But I am well and I am healthy.  I live a full and active life.  I am a wife to a non-diabetic husband.  I am a mother to a non-diabetic child.  I travel.  I exercise.  I live. I have fun.

          The Finer Detail…

          But I have to hang my head and say that I don’t TRULY know what diabetes is.  I’ve heard about the islets of Langerhans.  But I couldn’t explain to you what they are.  I know that my beta cells have been attacked by my immune system. But I can’t draw you a picture of what that  looks like.  And I don’t know why my immune system attacked my beta cells to start with.

          curing healing type 1 diabetes naturally

          Back To School

          I decided that the first stage of my healing process must include improving my knowledge levels.  How could I slay the beast without knowing what it looked like?  How could I understand what healing from T1D required if I didn’t know what its mechanism actually was?

          Understanding this process started with under the immune system.  Basically, the immune system functions in two main stages. Firstly, it detects foreign bodies, known as pathogens.  When pathogens are detected, the immune system sets about neutralising these pathogens.

          In healthy individuals, the immune system is so advanced that it is able to differentiate between pathogens and the normally functioning cells, tissues and organs of the human body.

          The dominant model to explain diabetes is the Eisenbarth model [1].  This model states that T1D is a chronic autoimmune disease where the immune system attacks the pancreatic beta cells.  It mistakenly identifies the beta cells in the pancreas as pathogens and sets about eliminating them [2].

          The Pancreas

          curing healing type 1 diabetes naturally
          The Position Of The Pancreas In The Body

          So here it is, the little beauty!  What strikes me most about this organ is how unnoticed AND unnoticeable it is!  If you ask most healthy people, they could describe where the major organs of the brain, heart, lungs, kidneys, stomach, bladder and bowel are located.  But the pancreas…?

          The pancreas is part of the digestive system.  It is conveniently situated behind the stomach.  It has both endocrine and exocrine functions.  The endocrine functions are mostly focussed on regulating blood sugar levels.  It achieves this by secreting a series of hormones, including insulin, straight into the bloodstream.  The exocrine functions involve supplying the stomach with digestive enzymes.  These enzymes break food down into carbohydrates, proteins and fats.

          What Are Beta Cells?

          pancreatic cell
          The Structure Of The Pancreas And Pancreatic Islets

          There are three types of endocrine cells:

          • Alpha Cells: secrete glucagon. Glucagon is responsible for stimulating the liver to convert glycogen stores into ready-to-use glucose.
          • Beta Cells: secrete insulin.
          • Delta Cells: produce somatostatin that inhibits the secretion of glucagon and insulin.

          All three are found in the pancreatic islets.  These pancreatic islets are also known as the ‘islets of Langerhans’.  These were named after the German anatomist Paul Langerhans, who discovered them in 1869.

          Researchers generally posit that T1D occurs when the majority (between 70-90%) of the beta cells have been destroyed [3], [4], [5], [6].  Without these beta cells, the pancreas is unable to produce enough insulin to maintain healthy blood sugar levels.

          Beta Cell Mass and Beta Cell Function

          Now this is where, for me, things got a bit more murky.  More recent research [8] suggests that the lack of sufficient insulin in diabetes could in fact result from two different factors:

          • Reduced beta cell mass: there are fewer working beta cells in the pancreas due to increased beta cell death.
          • Reduced beta cell function: the beta cells are still alive and well in the pancreas but they are in a dormant/non-functioning state.

          So which one is relevant to Type 1 Diabetes?  It would appear that the answer is… BOTH!  For T1D that developed before the age of 14, there appears to be a higher number of inflamed islets (suggesting a reduction in their functioning) and also a lower number of remaining beta cells [9].  For T1D developed in the teenage years, however, beta cell mass is still surprisingly high [10].  The beta cells are still there, just not working right! It is thought that the marked increase in the loss of beta cell mass in the early years of Type 1 Diabetes is due to an increased level of the inflammatory process ‘insulitis’ [10].

          Why Were My Beta Cells Inhibited And/Or Destroyed?

          I have millions of cells in my body that do thousands of different jobs so why on earth did my rampaging, rebellious, body-wide immune system choose to turn in on my beta cells?  That’s pretty specific!  Why not the cells responsible for producing nasal mucus (that’s snot and bogeys to you and me!!)?  I’d prefer to do without those!

          Well, now the next piece of the story unravels… It turns out that the immune system in T1D may actually be working perfectly.  Instead, it is the beta cells that become dysfunctional [11].  This dysfunction causes the immune system to (quite correctly) identify them as pathogens, unhealthy to the system.  It therefore sets about clearing them out.

          Is All Hope Lost?

          Okay, soldier, not so quick on the draw!!  Despite all the gloom and doom about total beta cell loss, I have found some avenues of hope.
          Firstly, some interesting findings concerning C-Peptide. C-Peptide and insulin are produced and released from the pancreas at the same time and in similar quantities.  Thus, measuring C-Peptide can give a fairly good indication of the level of insulin that the pancreas is producing.  It has been found that 88% of T1D still have functioning beta cells, even many years after diagnosis and therefore also still have measurable levels of C-Peptide[12]. Thus, for these lucky individuals, half the battle is won.  Unfortunately, my doctor has confirmed that my C-Peptide level is so small that it’s unmeasurable… Unfortunately, I ain’t in that ‘my-pancreas-is-still-performing-pretty-well’ camp!!

          Secondly, research does not seem to support Eisenbarth’s proposal that great numbers of beta cells have been destroyed by the immune system…  In fact, only modest increases in beta cell death have ever been found in T1D [13].  So the beta cells might not even be dead…?!

          Instead, researchers [14] have demonstrated that the pancreas of T1Ds hold a larger-than-normal number of delta cells in their pancreas.  Therefore, they suggest that, instead of the beta cells dying, they have been converted from insulin-producing beta cells into insulin-inhibiting delta cells.  These same authors also found that this cell transformation is reversible, meaning that the delta cells can be changed back into fully-functioning beta cells under laboratory conditions.

          Thirdly, it has been found that when beta cells from Type 2 Diabetics are taken out of the ‘stressful stimulus’ provided by their bodily environment, they started producing insulin again [15].

          Fourthly, cutting-edge research has found that the pancreas has its own back-up system in place!  Hidden in plain sight from researchers for over one hundred years is a population of baby beta cells tucked up around the edges of healthy pancreatic cells [16].  These baby cells can already produce some insulin. I therefore wonder if it’s possible to grow these into fully-functioning ‘adult’ beta cells to restore insulin production in the pancreas.

          Hope Still Exists!

          These four findings give me great hope.  Although I do not have any measurable C-Peptide, I may still have dormant beta cells (which therefore are not producing C-Peptide).  These may just need a wake-up call to get going again.  However, even if I don’t have these dormant but healthy beta cells that can go forth and multiply, I still do have a source for creating new ones… The baby beta cells in the periphery of my pancreatic cells. Furthermore, the notion that the environment of the cell may inhibit insulin production makes me think about how I might change that environment myself to encourage beta cell proliferation.

          Rebooting The Pancreatic Cells

          So I need to find a way to reawaken my dormant beta cells (if I have any), and/or transform my delta cells back into fully-functioning beta cells and/or grow my baby beta cells into adult form.  As I have discussed above, beta cells can suddenly start producing when the environment they are in is changed.  This makes sense to me.  After all, how do you get a plant or an infant to grow?  You provide it with the right nutrition, environment and conditions for growth to take place.

          In my forthcoming blog posts, I will further support and expand upon the thoughts in this post.  Furthermore, I will be exploring a whole series of factors that I believe will contribute to the (re)growth of my beta cells.

          Summary

          • Type 1 Diabetes was originally understood to be an autoimmune disorder resulting from a misfiring immune system killing off the pancreatic cells that produce insulin (beta cells).
          • The beta cells are stored in pancreatic islet cells, along with alpha cells (that secrete glucagon) and delta cells (that produce somatostatin, which inhibits insulin and glucagon production).
          • Cutting-edge research is demonstrating that: i) the beta cells in the pancreas may not be destroyed after all; ii) beta cells have been transformed in the pancreas into insulin-inhibiting delta cells, which can be transformed back to beta cells; iii) changing the environment of inhibited beta cells can enable them to start producing insulin again; iv) the pancreas also contains baby beta cells that have the potential to develop into fully-functioning beta cells for those who do not have their own supply.
          • T1D appears to be more healable than the ‘beta cells have been burnt out’ theory suggests.

          Glossary:

          Alpha Cells: one of three types of cells found in the pancreatic islets. These are responsible for releasing glucagon to raise low blood sugar levels.

          Autoimmune disease: a disease caused by the immune system attacking cells or tissues in the human body that should not normally be attacked.

          Beta Cells: one of three types of cells found in the pancreatic islets. These are responsible for producing insulin, which lowers blood sugar levels.

          Beta Cell Function: a measure of the ability of the insulin-producing beta cells to produce insulin.

          Beta Cell Mass: a measure of the number of fully-functioning beta cells remaining in the pancreas.

          Blood sugar levels: a measure of the amount of glucose in the bloodstream. In diabetes, the body’s natural ability to maintain this at an optimum level is diminished.

          Carbohydrates: sugars, starches and fibres that are found in food stuffs. Carbohydrates are normally the body’s main source of energy, being utilised to increase blood glucose levels as and when required.

          Chronic: long-term.

          C-Peptide: an amino acid produced concurrently with insulin in the pancreas. A detectable level of C-peptide in the bloodstream is indicative of insulin production in the pancreas.

          Delta Cells: one of three types of cells found in the pancreatic islets. These are responsible for inhibiting the production of glucagon and insulin from the alpha and beta cells respectively.

          Eisenbarth model of diabetes: the currently dominant model of diabetes used by the majority of researchers and doctors to explain how T1D occurs. It suggests that T1D results from the immune system attacking and breaking down the beta cells in the pancreas, thus causing hyperglycaemia.

          Hyperglycaemia: the presence of too much sugar in the bloodstream.

          Hypoglycaemia: the presence of too little sugar in the bloodstream.

          Immune System: this is a complex, body-wide system that protects a body against pathogens and disease. It consists of many cells, organs and tissues of the anatomy.

          Insulin: a hormone produced by the beta cells in the pancreas. It is responsible for lowering glucose levels in the bloodstream.  In T1D, insufficient insulin is produced by the pancreas.  The lacking insulin is replaced with external insulin, either via injection or insulin pump.

          Insulitis: a disease of the pancreas where immune cells infiltrate the pancreatic islets, causing beta cell loss.

          Islets of Langerhans: also known as pancreatic islets. Each one is a specific small area of the pancreas that contains three main cells that are responsible for producing hormones; alpha cells, beta cells and delta cells.

          Pancreas: an organ of the body, situated behind the stomach. It has roles to play in both the digestion of food and regulation of blood sugar levels in the bloodstream.  In T1D, one small part of the pancreas, the beta cells, no longer produce insulin.

          Type 1 Diabetes (T1D): an autoimmune disease that occurs when the immune system attacks and destroys the insulin-producing beta cells in the pancreas.

          References:

          Pugliese, A., and Skyler, J. S. (2013). George S. Eisenbarth: Insulin and Type 1 Diabetes.  Diabetes Care, 36(6), 1437-1442. [Article]

          Holt, R. I. G., and Hanley, N. A. (2012). Essential Endocrinology and Diabetes.  Chichester, UK and Hoboken, NJ: Wiley-Blackwell Publishers. [Book]

          Gepts W. (1965). Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes, 14(10), 619–633. [Article]

          Gepts W., and De Mey J. (1978).Islet cell survival determined by morphology: An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus.  Diabetes, 27(S1), 251–261. [Article]

          Junker K., Egeberg J., Kromann H., and Nerup J. (1977). An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology, 85(5), 699–706. [Article]

          Kloppel G., Drenck C. R., Oberholzer M., and Heitz P. U. (1984). Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. Virchows Archiv A Pathological Anatomy and Histopathology, 403(4), 441–452. [Article]

          Chen, C. et al. (2017).Human Beta Cell Mass and Function in Diabetes: Recent Advances in Knowledge and Technologies to Understand Disease Pathogenesis.  Molecular Metabolism, 6(9), 943-957. [Article]

          Atkinson, M. A., von Herrath, M., Powers, A. C., and Clare-Salzler, M. (2015). Current Concepts on the Pathogenesis of Type 1 Diabetes — Considerations for Attempts to Prevent and Reverse the Disease.  Diabetes Care, 38(6), 979-988. [Article]

          https://www.telegraph.co.uk/news/health/news/12146841/Type-1-diabetics-have-sleeping-insulin-cells-which-could-be-woken-say-scientists.html

          Sims, E. K., and DiMeglio, L. A. (2019). Cause or effect?  A review of clinical data demonstrating beta cell dysfunction prior to the clinical onset of type 1 diabetes.  Molecular Metabolism, 27S, S129-S138. [Article]

          Oram, R. A., Sims, E. K., and Evans-Molina, C. (2019). Beta cells in type 1 diabetes: mass and function; sleeping or dead?  Diabetologia, 62(4), 567–577. [Article]

          Butler A. E. et al. (2007).Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia, 50(11), 2323–2331. [Article]

          Piran, R., Lee, S. H., Li, C. R., Charbono, A., Bradley, L. M., and Levine, F. (2014). Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes. Cell Death and Disease, 5, e1357. [Article]

          Jeffery, N., et al. (2019).Cellular Stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Available at: https://ore.exeter.ac.uk/ repository/ bitstre am/handle/10871/37184/Jeffery%20et %20al.,%20HMG%202019.pdf?sequence=1.

          van der Meulen, T., et al. (2017).Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.  Cell Metabolism, 25(4), 911-926. [Article]

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            Natalie Leader

            Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

            The content of the HealingT1D website is for educational and information purposes only.  It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime.  HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.
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