Second Health Review

Where My Health Is Now

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: The author outlines her second health assessment on her healing journey.

Here is my latest progress update! I have updated the figures that I have measured since my last health review. All others, I have left in here for sake of completeness.

I have grouped my results into two sections:

‘Output‘ are the readings that I have had taken, including blood work, weight etc.
‘Input‘ are the things I do to try to help my body (or not, as the case may be!).

PLEASE NOTE: I am not a doctor/physician. My interpretations are my views only. They represent what I have come to understand through my research and therefore should not be considered medically interpreted.

For ease of interpretation, I have grouped my results into categories, according to my own standards of what I wish to attain…

My healthy results are in green
My results in need of improvement are in orange
My results in need of great improvement are in red

Output

Vital Statistics:

Height: 172 cm

Weight: 82 kg

BMI: 27.7

Fitness:

Average Minutes of Exercise (Last Seven Days): 38.6 minutes

Average Number of Hours of Sleep (Last Seven Days): 7.3 hours

Maximum number of sit-ups (to failure): 12 (Last six-week review: 7 sit-ups)

Plank (time to failure): 63 seconds (Last six-week review: 48 seconds)

Maximum Number of Push-ups (to failure): 13 (Last six-week review: 8 push-ups)

Time Taken to Cover One Mile: 11 minutes 59 seconds (Last six-week review: 12 minutes 35 seconds)

Resting Heart Rate: 64 bpm (Last six-week review: 66 bpm)

Diabetes:

HbA1c: 62 mmol/mol

Years of diabetes: 38

Complications: Intermittent background retinopathy. This tends to heal itself between one check-up and the next. I have no background retinopathy currently and no other complications.

Inflammation:

CRP HS: 4.5 mg/l

ECR (Erythrocyte Sedimentation Rate): 5 mm/hr

Interleukin 6 (IL-6): < 1.5 pg/ml

Kidney Health:

Urea: 4.5 mmol/L

Creatinine: 68 umol/L

EGFR: 88

Uric acid: 160 umol/L

ACR: 0.3 ug/mmol

Kidney Health:

Bilirubin: 5 umol/L

ALP: 68 IU/L

ALT: 32 IU/L

GGT: 33 IU/L

Proteins:

Total Protein: 64 g/L

Albumin: 42 g/L

Globulin: 22 g/L

Proteins:

Total cholesterol: 3.9 mmol/L

LDL cholesterol: 1.7 mmol/L

Non HDL cholesterol: 2 mmol/L

HDL cholesterol: 1.9 mmol/L

Total cholesterol: HDL : 2.1

Triglycerides: 0.6 mmol/L

Vitamin and Mineral Blood Readings:

Iron: 13.8 umol/L

TIBC: 44 umol/L

Transferrin Saturation: 31%

Ferritin: 112 ug/L

Magnesium – serum: 0.73 mmol/L

Folate – serum: 14.4 ug/L

Vitamin B12 – Active: 137 pmol/L

Vitamin D: 73 nmol/L

Thyroid Functioning:

TSH: 0.84 mIU/L

Free T3: 4.8 pmol/L

Free Thyroxine: 15 pmol/l

Improvements in My Output:

I have lost some weight and therefore decreased my BMI (although it is still currently too high). My fitness has also improved on all measures, which I am proud of. I am still being a bit lazy with my exercise – it’s what naturally happens in my week, rather than any planned activities. I also want to start focusing on my sleep. I am better if I have at least 7.5 hours a night so this will be an area for me to focus on.

My Subjective Assessment of My ‘Output’:

Although making improvements in my weight and fitness levels, I still feel pretty tired most of the time. I am going to address my sleep patterns and improve my fitness more as a way to address this.

My nutrition has improved dramatically since the last review – as I was expecting would happen when eating solely natural foods on Whole30! I hope that, as I continue to eat well for my body, my fitness and general feeling of wellbeing will continue to improve.

Input:

Medications:

I don’t take any medications at all, apart from insulin.

Diabetes:

Carbohydrates per day (average of the last week): 44.6 grams

Insulin dosages per day (average of the last week): 18.2 units consisting of 7.2 units of Novorapid and 11 units of Lantus (5 units of Lantus at night and 6 units of Lantus in the morning)

Vitamin And Mineral Supplements Taken:

None taken. Some were not compliant with Whole30. I also felt that, eating a more nourishing diet, consisting of a lot more fruit and vegetables, would also likely negate the needs for any supplements. I therefore stopped taking all supplements. I have been monitoring my mental health and… So far, so good!

My Subjective Assessment Of My ‘Input’:

I have significantly improved my carbohydrate intake and therefore significantly lowered my insulin requirements.

I have removed my vitamins and supplements without any noticeable effect. I attribute this to my dramatically improved diet, with a significant increase in my fruit and vegetables intake, as well as a complete elimination of processed foods, sugar, dairy and wheat.

My exercise levels are still well below what I would hope they would be. I will be aiming to start to address this in the forthcoming weeks.

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

January 20, 2020

First Health Review

25th November 2019

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: The author outlines her first health assessment. Blood results and also some subjective health assessments. are discussed. Whilst it may not appear to be particularly exciting reading, this is effectively the ‘before’ photo in the healing journey.

Formatting of this Post

I have grouped my results into two sections:

‘Output‘ are the readings that I have had taken, including blood work, weight etc.
‘Input‘ are the things I do to try to help my body (or not, as the case may be!).

For ease of interpretation, I have grouped my results into categories, according to my own standards of what I wish to attain…

My healthy results are in green
My results in need of improvement are in orange
My results in need of great improvement are in red

PLEASE NOTE: I am not a doctor/physician. My interpretations are my views only. They represent what I have come to understand through my research and therefore should not be considered medically interpreted.

Output:

Vital Statistics:

Height: 172 cm

Weight: 86 kg

BMI: 29

Fitness:

Average Number of Hours of Sleep (Last Seven Days): 7.2 hours

Average Minutes of Exercise (Last Seven Days) 17.1 minutes

Plank (time to failure): 48 seconds

Maximum number of sit-ups (to failure): 7

Maximum number of push-ups (to failure): 8

Time Taken To Cover One Mile: 12 minutes 35 seconds

Resting Heart Rate: 66 bpm

Diabetes:

HbA1c: 62 mmol/mol

Years of diabetes: 38

Complications: Intermittent background retinopathy. This tends to heal itself between one check-up and the next. I have no background retinopathy currently and no other complications.

Inflammation:

CRP HS: 4.5 mg/l

ECR (Erythrocyte Sedimentation Rate): 5 mm/hr

Interleukin 6 (IL-6): < 1.5 pg/ml

Kidney Health:

Urea: 4.5 mmol/L

Creatinine: 68 umol/L

EGFR: 88

Uric acid: 160 umol/L

ACR: 0.3 ug/mmol

Liver Health:

Bilirubin: 5 umol/L

ALP: 68 IU/L

ALT: 32 IU/L

GGT: 33 IU/L

Proteins:

Total Protein: 64 g/L

Albumin: 42 g/L

Globulin: 22 g/L

Cholesterol:

Total cholesterol: 3.9 mmol/L

LDL cholesterol: 1.7 mmol/L

Non HDL cholesterol: 2 mmol/L

HDL cholesterol: 1.9 mmol/L

Total cholesterol: HDL : 2.1

Triglycerides: 0.6 mmol/L

Vitamin and Mineral Blood Readings:

Iron: 13.8 umol/L

TIBC: 44 umol/L

Transferrin Saturation: 31%

Ferritin: 112 ug/L

Magnesium – serum: 0.73 mmol/L

Folate – serum: 14.4 ug/L

Vitamin B12 – Active: 137 pmol/L

Vitamin D: 73 nmol/L

Thyroid Functioning:

TSH: 0.84 mIU/L

Free T3: 4.8 pmol/L

Free Thyroxine: 15 pmol/l

I am overweight and my BMI is higher than it should be. I am definitely making weight loss part of my health goals. I suspect that this may naturally take place as I progress through this healing process anyway.

My Objective Evaluation Of My Bloodwork:

My HbA1c is greater than it could be. I have had it lower than this. I have been a bit lazy in the last few months. Like my weight, I suspect that my HbA1c will naturally improve as this process continues.

My CRP (high sensitivity) is within normal range but heading towards the top end. I suspected that my inflammation levels were likely to be elevated as a result of my diabetes and excess weight (although I note my other inflammation tests, IL-6 and ECR, are in the healthy range). I am intending to improve my nutrition quite substantially and thus hope to see improvement here.

All other blood results were at healthy levels.

My Subjective Assessment of My ‘Output’:

My blood work seems generally good, although there are a few ‘out-of-range’ values that I’ll be working on through lifestyle adjustments. I will be particularly focusing on my diet and exercise from here to try to improve those readings.

Despite having a generally healthy picture in my blood panel, I don’t generally feel that great. I don’t feel ill but I just don’t feel like a picture of health. I feel tired by the end of the day most days. I am sometimes irritable. I can feel sluggish in my day-to-day activities. So, whilst I would not be deemed ‘unwell’ by a medical professional, I still feel I can reach for more than I have now.

I don’t exercise particularly frequently and do not take particularly good care of my body’s nutritional needs. I do a sufficient amount to look after my diabetes but I know could fine-tune that too. I would like to substantially increase my general fitness level and increase my cardio workouts. There is definitely work for me to do over the forthcoming months!

Input:

Medications:

I don’t take any medications at all, apart from insulin. No, not even statins (strangely, I’ve never been offered these, despite 38 years of diabetes).

Diabetes:

Carbohydrates per day (average of the last week): 150-200 grams

Insulin dosages per day (average of the last week): 48.2 units consisting of 30.2 units of Novorapid and 18 units of Lantus

Vitamin and Mineral Supplements Taken:

Every Day:

Pure Fish Oil 1100mg with 70mg Omega 3s
Vitamin D3 (Cholecalciferol) 4000 IU
Multivitamin containing: 667 micrograms Vitamin A; 16 mg Vitamin E; 24.5 micrograms Vitamin K; 1.32 mg Vitamin B1; 2.1 mg Vitamin B2; 2.1 mg Vitamin B6; 3 micrograms Vitamin B12; 10 micrograms Vitamin D; 62.5 micrograms Biotin; 300 micrograms Folic Acid; 16 mg Niacin; 7.5 mg Pantothenic Acid; 320 mg Calcium; 105 mg Phosphorus; 100 mg Magnesium; 10 mg Iron; 100 micrograms Iodine; 500 micrograms Copper; 2 mg Manganese; 40 micrograms Chromium; 50 micrograms Molybdenum; 30 micrograms Selenium
Passion Flower Herb, 2 capsules totalling 600 mg
Ashwagandha totalling 300 mg
Zinc totalling 35 mg
Vitamin C totalling 240 mg

Every Week:

Evening Primrose Oil 500mg

Whilst I feel that this looks like a lot of supplements, I have honed these over a period of years to optimise my subjective experience of feeling well. I did suffer a lot from anxiety and depression. I believe that this combination of vitamins and minerals play a part in helping me to keep these mental health conditions at bay.

My Subjective Assessment Of My ‘Input’:

My carbohydrate intake (and therefore my insulin requirements) are too high. I will be addressing these in the forthcoming weeks.

I am happy with the vitamin and supplement regime I am on and I am happy with the lack of other medications I put into my body.

My exercise levels are well below what I would hope they would be. They have been much better than this for large periods of my life. However, I want to be cautious about increasing my exercise levels too high too soon because I will not sustain it. A little bit more every week until I get to the point of doing some form of exercise everyday will be a good start. I hope this will then yield gradual improvements in my fitness levels (as measured by my sit-ups, push-ups, plank performance and 1 mile run time).

It’s definitely time for me to get started!

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

November 25, 2019

My Reasons for Healing My Type 1 Diabetes

A Key Factor In Healing

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: The author discusses the importance of having a strong reason for healing and outlines her own.

To Tell Or Not To Tell… That Is The Question!

As I have already discussed in my article on Candace Pert, one of the main healing factors is having a strong reason for healing. Motivation is key.

Kelly Turner [1; see also my post here on this subject] outlined that you should have a strong reason for living/healing. However, she did not discuss whether one’s reasons for healing should be shared or not.

I was unsure whether or not I should tell you my reasons for healing my Type 1 Diabetes. There seems to be a large amount of psychology research out there saying that I should NOT say… That it can decrease motivation by doing so [2].

On the other side of this coin, though, is the fact that I have decided to be fully open about my process towards healing, so that you can feel empowered to do it too. Revealing the facets of my motivation therefore sheds more light on my process and the conditions within which my healing takes place.

On top of that, I am hugely stubborn. I don’t like taking no for an answer. I also do not, not, NOT like showing myself up. If I say I’m going to do something, I ain’t backing out of it. Particularly when I’ve broadcast it to the world! Accountability really rocks for me…! So here goes…

My Reasons For Healing My Type 1 Diabetes

This is my purpose in life. I feel that the experiences I have gained throughout my life, both inside and outside of medicine, have set me up for this path. I am now coming into my own by following it.
My daughter nearly became diabetic, being considered ‘pre-diabetic’ by doctors at one point. If she does cross that threshold in the future, I want to be able to offer her a way of healing, rather than just a method of treatment.
I would like to help convert medicine into a more holistic discipline that can offer the very best mutlifaceted treatments to all that need them.
I would like to feel healthy and well during as many moments as possible in my life.

References:

[1] Turner, K. A. (2010). Radical Remission: Surviving Cancer Against All Odds. New York: HarperCollins. [Link]

[2] Gollwitzer, P., Sheeran, P., Michalski, V., and Siefert, A. (2009). When Intentions Go Public: Does Social Reality Widen the Intention-Behavior Gap? 20(5), 612-618. [Link]

GET HEALINGT1D’S FUTURE ARTICLES IN YOUR INBOX!

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

November 11, 2019

9 Key Factors For Healing

And Only Four Involve The Physical Body!

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: This article explores the work of Dr Kelly Turner, who has identified nine key factors that are key to healing cancer. After outlining what these factors are, the author argues that these factors are likely to be required for healing the body from any condition.

Diabetes Resulting From A Lack of Emotional Expression

Whilst burying my nose in books and various other sources on diabetes and/or healing, I came across the PhD thesis of Kelly Turner [1].

This amazing piece of work sought to find an explanation for people who had spontaneously healed from cancer, after they had been given a terminal diagnosis or had stopped medical treatment.

What particularly drew me in was a conversation that Kelly Turner had with an oncologist from Japan (known as Healer #27 in her thesis). This healer stated that he believed that cancer and also diabetes, amongst other medical conditions, were mainly caused by a lack of emotional expression (known as ‘alexithymia’ by mental health professionals).

This healer’s ideas sound quite bizarre to the mind of Western medicine, where the body is treated by the doctor and the mind is treated by the psychologist or psychotherapist.

However, the neuroscientist Candace Pert has beautifully demonstrated the intricate links between the physical and emotional system and particularly insulin’s starring role in this process (see my post on Candace Pert’s work here). Diabetes resulting from a lack of emotional expression doesn’t sound so ‘alternative’ anymore. I know that, in my life, I can struggle to express myself. I often withdraw from confrontation or do not speak my whole truth. Having had diabetes for a long time, I have had more than a few times when I have had to ‘suck it up’ to get through medical treatments.

If Lack of Emotional Expression Has Caused (Or Contributed) To My Type 1 Diabetes, How Do I Reverse It?

Kelly Turner’s inspirational work doesn’t stop there. Having conducted numerous interviews with people who spontaneously healed from cancer, Kelly Turner [2] found that they all shared a series of factors that they felt contributed to their healing. She outlines these nine factors in her New York Times bestselling book ‘Radical Remission: Surviving Cancer Against All Odds’ (a book I highly recommend reading!).

Kelly Turner’s 9 main key healing factors, plus two that she states may be potential factors in the introduction to her book, are:

Kelly Turner’s 9 Key Factors For Healing:

Radically Changing Your Diet
Using Herbs and Supplements
Taking Control of Your Health
Releasing Suppressed Emotions
Promoting Positive Emotions
Embracing Social Support
Deepening Your Spiritual Connection
Following Your Intuition
Having A Strong Reason For Living

Kelly Turner’s Possible Additional Two Factors For Healing (Still To Be Researched):

Applying The 9 Key Factors to T1D

As I read through these factors, a couple of things really struck me:

1. The Healing Factors Did Not Appear To Be Specific To Cancer

Since these factors did not seem specifically tailored to cancer treatment, I wonder if these may be factors that are general to healing the human body, not just cancer.

2. Only Four of the Factors Directly Involve the Physical Body

‘Radically changing your diet‘, ‘Using herbs and supplements‘, ‘Taking Control of Your Health‘, and ‘Exercise‘ concern the physical body. The other seven factors concern mental, emotional or spiritual interventions. This shows to me that healing T1D cannot just involve the body. I must widen my remit to include the mind and spirituality too.

My Route Forward….

Having made the assumption (which also feels intuitively correct) that these 9 key factors are responsible for healing the human body, I am using them as the basis for my healing plan going forward.

There is an obvious revision that I need to make to the factor ‘Having a Strong Reason For Living‘. Unlike people with terminal cancer, I am not at-risk of an imminent death. Therefore, this factor appears a bit irrelevant to my healing. I am going to change this factor to ‘Having A Strong Reason For Healing’.

I hope that using these factors will produce a more hospitable environment in which my new beta cells can grow (or my delta cells can transform back into beta cells!).

However, I am also open to these factors changing or adapting as my work progresses. Perhaps there are differences between healing cancer and healing T1D that I do not yet know. However, these factors seem like a good place to start.

References:

1. Turner, K. A. (2010). Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors. PhD thesis, University of California, Berkeley. [Link]

2. Turner, K. A. (2014). Radical Remission: Surviving Cancer Against All Odds. New York: HarperCollins. [Link]

GET HEALINGT1D’S FUTURE ARTICLES IN YOUR INBOX!

Get the latest musings and findings straight to your email inbox.

Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

October 28, 2019

Self-Experimentation

The Method To Use For Healing Type 1 Diabetes

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: This article considers the method of self-experimentation. Self-Experimentation is defined and its history is explored. Consideration is then given to using self-experimentation for healing Type 1 Diabetes and its potential challenges.

I now find myself in a place that I never expected to be in… Where I am prepared to take risks, and be taking risks of the calculated variety, to heal my own Type 1 Diabetes. This puts me squarely in the field of self-experimentation.

What Is Self-Experimentation?

Self-experimentation is single-subject research, also known as n = 1 experiments (since the number of participants in the experiment is one). In these experiments, the researcher and participant are most often the same person, testing their hypotheses on themselves. It is often thought that self-experimenters are rogues, ‘members of a lunatic-fringe of science’ [1]. However, self-experimentation has a richly-documented medical history that has provided a plethora of Nobel prizes and significant advances in many fields of science [2]. It has been used most often in the fields of medicine and psychology.

A Brief History of Self-Experimentation

Self-experimentation has been employed in research since its inception. Self-experimentation is often used to avoid the need for ethical approval necessary to conduct research experiments on humans.

Ethical regulation for human experiments can be traced back to the Nuremberg Code. The Nuremberg Code was the first code of law and ethics to be established for human experiments. Its development was a reaction to the horrific medical experiments undertaken on humans by Nazis in concentration camps [3].

Specific reference to self-experimentation is referenced in article 5 of the Nuremberg Code:

‘No experiment should be conducted if there is an a priori reason to believe that death or disabling injury will occur, except, perhaps, in experiments where the experimental physicians also serve as subjects’.

This permit for self-experimentation has, over the years, yielded breakthrough findings and medical advances in numerous specialties of medicine, including: yellow fever, leukaemia, cancer, rabies, HIV vaccines, staphylococcal infection, anaesthesia, typhoid and scurvy [4]. However, not all adventures into self-experimentation have been risk-free, with death, disease and disability resulting from several such experiments [5, 6].

Nobel prizes in the categories of Physiology or Medicine have been achieved several times by self-experimenters.

Barry Marshall, an Australian doctor, was awarded the Nobel prize for Physiology and Medicine in 2005. He believed that a bacteria strain called Helicobacter pylori, was responsible for the development of gastritis and stomach ulcers. Marshall faced derision and disbelief from the medical community when he argued that bacteria could survive in the stomach and produce peptic ulcers. Unable to replicate peptic ulcers in pigs infected with the Helicobacter pylori bacterium, Marshall took it upon himself to swallow a batch of this bacteria strain.

Within a week, he had developed gastritis (the precursor to peptic ulcers) and was suffering the symptoms of nausea, vomiting and halitosis (that’s bad breath to you and me!). He then successfully treated it with a course of antibiotics [7].

Ralph Steinman, MD, having been given a terminal diagnosis of pancreatic cancer, subjected himself to eight different experimental therapies to attempt to increase his 5% chance of living longer than a year. He attributed his unexpected additional four and a half years of life to these experimental procedures. In 2011, Steinman was awarded the Nobel prize for his discovery of the dendritic cell type.

Self-Experimentation In Diabetes Research

Interestingly, self-experimentation also touches the field of diabetes research. Frederick Banting, one of the discoverers of insulin (see my article here for more information), gave himself mustard gas burns when attempting to find ways to treat such burns [8].

Similarly, I see diabetes treatment itself to be a form of self-experimentation. Every day as a diabetic, I have to experiment on myself with insulin dosing, activity levels, emotional responses (stress, anger etc) to attain optimal blood glucose levels. Each day is a new experiment as the physiology of my body and the external demands of my environment fluctuate in their demands and requirements.

A relatively new addition to the self-experimenters in diabetes research are a small community of diabetic patients who have created their own artificial pancreases. Using a security flaw in old Medtronic insulin pumps, hackers have been able to create software that converts the pump into a closed feedback loop system that both monitors blood sugar levels and then inputs calculated insulin doses via the pump [9].

These patients are the latest self-experimenters in diabetes research. However, they have been greeted with disapproval by the FDA and a lack of support from Medtronic.

Limitations of Self-Experimentation

Self-experimentation is obviously not without some limits. The most major of these is generalisability. In other words, just because I make this work for me does not mean it will work for you. This may be particularly true in this field, where I am arguing that the mind has as much of an impact as the body in the healing process. I am obviously undertaking this blog because I believe in what I am doing. Therefore, if my strong belief affects my body (I will be writing on this topic soon) then my healing might not be repeatable for those without belief.

Am I Qualified For Self-Experimentation?

So, it would now appear that I am going to be the ‘1’ in the n = 1 experiments in this blog!!

Am I qualified to take on such a role? I learnt research design and implementation through my degree in Psychology and also through my Masters in Counselling and Psychotherapy. From this training, I know that, in order to be scientifically robust, my research must have a clear hypothesis to start with.

From this hypothesis, I must design a research method that directly answers my hypothesis. Through a robust research design, I then derive results that can be analysed and conclusions drawn. Unfortunately, I don’t think my research will fit neatly into such a paradigm. After all, I am not looking at a thoroughly scientific approach. I am seeking to investigate if diabetes is curable through the body’s own processes and whether these can be activated by means that are not necessarily medical.

In order to not have confounding results, it is really important that I control for extraneous variables. Unfortunately, this is where I may come into issues. If I expand the remit of what can effect the healing of diabetes to include the environment, both of the body and the external environment it finds itself in, and consider Type 1 Diabetes to be a mind-body disorder, then the possible influences on this matrix are vast and, at this moment in time, perhaps even not yet fully known. Therefore, controlling for these does not seem very possible.

Whilst this may make my design for my n=1 experiments flawed, I do not believe these experiments will be any less flawed than those of medicine. Medical studies into Type 1 Diabetes currently only consider it through a medical lens. Thus, inputs from mental and spiritual components are not controlled for in these studies. Therefore, all medical studies are currently flawed.

If someone heals from Type 1 Diabetes, a genetic or bodily cause is sought. Has anyone thought to look for mental, emotional or spiritual components that my have had an impact? Therefore, all medical research into diabetes development and healing is also flawed. Their lens is too narrow.

I don’t intend to be reckless with my self-experimentation. I am a hugely experienced diabetic who has ridden the challenges of diabetes is all weathers and health scenarios for nearly forty years. I bring to the table a wealth of knowledge about my own condition and its peculiarities. This is the foundation from which I will be experimenting. I will not be going in blind.

The only major risk I can see at this point is potential death resulting from abruptly stopping my insulin. I have absolutely no intention of doing this. I anticipate that, as my diabetes starts to heal, I will witness my blood glucose levels decreasing as my pancreas starts producing its own insulin. The risk of hypoglycaemia(s) associated with this increased level of insulin in my body is also not without risk. I therefore need to be vigilant with my blood glucose control during these experiments and respond diligently to fluctuations in my control. This requirement, however, is something that I respond to on a daily basis as part of my diabetes management.

References:

Kerridge, I. (2003). Altruism or reckless curiosity? A brief history of self experimentation in medicine. Internal Medicine Journal, 33, p. 204. [Link]

Altman, L. (1998). Who Goes First?: The Story of Self-Experimentation in Medicine. London, UK and Berkeley and Los Angeles, CA. University of California Press. [Link]

Ghani, R. (2011). Self experimenting doctors. British Medical Journal, 342, d2156. [Link]

Kerridge, I. (2003). Altruism or reckless curiosity? A brief history of self experimentation in medicine. Internal Medicine Journal, 33, 203-207. [Link]

Mapes, M. (2015). Mad Scientists: When the Scientist Becomes the Subject. Accessed on 1st November 2019 from: https://endocrinenews.endocrine.org/mad-scientists/.

Weisse, A. B. (2012). Self-Experimentation and Its Role in Medical Research. Texas Heart Institute Journal, 39(1), 51-54. [Link]

Van Der Weyden, M. B., Armstrong, R. M., and Gregory, A. T. (2005). The 2005 Nobel Prize in Physiology or Medicine. Medical Journal of Australia, 183(11), 612-614 [Link].

Hanley, B., Bains, W., and Church, G. . Review of Scientific Self-experimentation: ethics, history, regulation, scenarios, and views amongst ethics committees and prominent scientists. Pre-publication draft. Accessed on 2^nd November 2019 from: http://arep.med.harvard.edu/pdf/Hanley_Bain_Church_2018.pdf

Zhang, S. (2019). People Are Clamoring to Buy Old Insulin Pumps: How an obsolete medical device with a security flaw became a must-have for some patients with type 1 diabetes. Accessed on 11^th November 2019 from: https://www.theatlantic.com/science/archive/2019/04/looping-created-insulin-pump-underground-market/588091/.

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

September 2, 2019

Allostatic Load

Re-Understanding The Development Of Type 1 Diabetes As Progression Along A Continuum

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: This article provides a conceptual framework for understanding the path to healing Type 1 Diabetes. Currently, the condition is seen as something that has ‘switched on’ in our bodies and remain there permanently. Perhaps instead we can use the concept of an ‘allostatic load’ to see T1D as a status that arrives when the environment of the cells has tipped towards too much toxicity or they are under too much challenge from areas such as the diet, feelings of the individual, amount of exercise, and all other life experiences. Using this concept, the focus then becomes about how to tilt that seesaw back towards health and healing.

Stress impacts the human body. We all know this! When stressed, our bodies produce a series of hormones to equip the individual to deal with a perceived or actual threat in the environment.

Hormones

There are two main types of hormones that are produced as a result of stress: glucocorticoids and catecholamines.

Glucocorticoids:

These are also known by the name glucocorticosteroids (which gives an impressive Scrabble score of 28 points!). These are part of the immune system feedback loop, which helps maintain homeostasis in the human body. One well-known glucocorticoid is cortisol, the ‘stress hormone’. Glucocorticoids have many functions, including:

1. An Ability To Stop Inflammation In The Body:

It does this by suppressing the release of molecules called proteins, which are used in the inflammatory process [1]. Glucocorticoids are therefore great at stopping the damage done by overactive immune system disorders, such as type 1 diabetes.

2. A Role In Regulation Of Glucose Metabolism:

Glucocorticoids encourage glucose production in the liver and also prevent insulin from working effectively to uptake glucose [2]. Glucocorticoids also affect pancreatic alpha and beta cell functioning [3]. This influences the amount of glucagon and insulin released into the bloodstream. The goal of glucocorticoids is to keep glucose in the bloodstream so that the brain, during times of stress, can work at maximum capacity [2].

Catecholamines:

Catecholamines (a mere 23 points in Scrabble!) are another type of hormone released during stressful life events. They are produced by my adrenal glands, which are located just above my kidneys. Examples of catecholamines are dopamine, norepinephrine and epinephrine (aka adrenalin). These hormones are sent into my bloodstream every time I get physically or emotionally stressed. Like glucocorticoids, catecholamines raise blood sugar levels, as well as heart rate, blood pressure and increased arousal of the sympathetic nervous system.

What Is Allostasis?

Both of these hormones, glucocorticoids and catecholamines, have beneficial short-term effects in the body. They prepare the body for a fight-or-flight response in times of stress or threat to life, for example. This process of adjusting the body, through physiological and/or behavioural changes, is known as ‘allostasis’ [4].

Allostatic Load

However, in the long-term, the process of allostasis can become disadvantageous and even burdensome on the body. Such a burden is known as the ‘allostatic load’ [4]. The higher my allostatic load, the more burden my body is carrying, in terms of raised blood glucose levels, higher stress levels, increased inflammation and so on. For example, chronic stress can lead to high levels of the glucocorticoid ‘cortisol’ (yes, that’s right, the ‘stress hormone’ as it’s known!). Chronically elevated cortisol levels can lead to:

- Anxiety
- Depression
- Digestive problems
- Sleep problems
- Weight gain
- Issues with memory [5]

How Is Allostatic Load Relevant To T1D?

Allostatic load is the burden the body has as a result of (ongoing) environmental stressors. It takes a toll on the system and, over time, creates a whole range of health issues [6].

Both the sympathetic nervous system and the neuroendocrine system (that’s the system that influences both hormones, like insulin, and neurons, including those in the brain) play central roles in the concept of ‘allostatic load’ [7]. In other words, chronic stress reduces insulin production and affects brain functioning. A lack of insulin production results in Type 1 (or Type 2 or MODY) Diabetes.

Dopamine is an example of a catecholamine. Insulin has been found to be strongly associated with the ‘pleasure’ centre of the brain, the striatal region, where dopamine is produced. [8]. The more insulin there is in the bloodstream, the more dopamine is released from the striatal region. Dopamine is a feel-good chemical. In a Type 1 Diabetic, when blood sugar levels are too high, the resulting mood is likely to not be a very fun one… Oh, I know that grumpiness of high blood sugars!! In a non-diabetic, I would anticipate that the reverse must be true… The more joy they experience, the more they are able to produce insulin.

In my post on Descartes and the Mind-Body Split in Western Medicine, I touched upon the research that highlights a connection between stressful life events and subsequently developing T1D. As discussed, chronic stress releases glucocorticoids and catecholamines that shut down insulin production and increase glucose concentrations in the blood. So perhaps the reverse can be true…? If I can reduce my allostatic load, it gives my system more of a chance of increasing (starting!) insulin production. It makes my bodily environment more welcoming to growing some new beta cells (as discussed in my post ‘What is Type 1 Diabetes?’).

My Take-Home Message

For me, the concept of an allostatic load is something to hold going forward. Instead of understanding my beta cells as being burnt out or broken, I am seeing them as being in an environment that stops them from switching back on.

The environmental conditions in my body are fuelled by all the factors that contribute to my allostatic load. These include my diet, my feelings of helplessness, my exercise regime, my response to my life experience, the amount of daily stress I carry with me, and so on.

In other words, Type 1 Diabetes is a multifaceted disorder. Thus, each one of these things that I can improve or eliminate, the smaller the burden of my allostatic load will be. I am therefore looking to improve all areas of my life that I feel may contribute to my allostatic load and thus fundamentally reduce it. I will watch to see what happens to my blood sugar levels (and pancreatic function) from there!

Summary

Stress produces two types of hormones in the body: glucocorticoids and catecholamines.
Glucocorticoids stop inflammation in the body and increase and/or maintain blood glucose levels, ready for the individual to respond to threat.
Catecholamines raise blood sugar levels, as well as heart rate, blood pressure and arousal in the sympathetic nervous system.
Allostatic load is a measure of the amount of cumulative stress placed on a system due to adjustments the body makes to maintain homeostasis.
Allostatic load can be used conceptually to understand T1D. Healing from T1D, using this approach, requires an overall reduction on stressors in the system that can contribute to a high allostatic load.

After-Thought…

Writing this post has also given me some food for thought on a related point… The dominant model for understanding Type 1 Diabetes is the Eisenbarth model (see my post on ‘What is Type 1 Diabetes?’ for more info on this). If researchers are using this model as their way of understanding T1D, they are going to assume that the beta cells in the pancreas are burnt out. Therefore, measuring the C-peptide, for example, once only is a sufficient indicator of the amount of insulin-producing cells left in that individual’s pancreas.

However, if that model is flawed and insulin production fluctuates with allostatic load over the course of a day, a week or a month, then measuring C-peptide would only indicate the amount of functioning beta cells at that moment in time. The C-peptide test is most often done, if at all, in the early days after diagnosis of T1D. At such a stressful time of life, when your allostatic load is likely to be huge, a low C-peptide level would almost be guaranteed. This would give an explanation for the ‘honeymoon effect’ of a lot of T1Ds since, after diagnosis, they are often looked after mentally, physically and emotionally by those around them.

References:

Barnes, P. J. (1998). Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clinical Science (London), 94(6), 557-572.
Kuo, T., McQueen, A., Chen, T. C., and Wang, J. C. (2015). Regulation of Glucose Homeostasis by Glucocorticoids. Advances in Experimental Medicine and Biology, 872, 99-126.
Rafacho, A., Goncalves-Neto, L. M., Santos-Silva, J. C., Alonso-Magdalena, P., et al (2014). Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats.PLoS One, 9(4), e93531.
McEwen, B. S. (2000). Allostasis and Allostatic Load: Implications for Neuropsychopharmacology. Neuropsychopharmacology, 22, 108-124.
Talbott, S. M. (2007). The Cortisol Connection: Why Stress Makes You Fat and Ruins Your Health – And What You Can Do About It. Nashville, TN: Hunter House.
McEwen, B. S. (2000). The Biological Basis for Mind Body Interactions. Progress in Brain Research, Vol 122. New York: Elsevier.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T., and Glaser, R. (2002). Psychoneuroimmunology: Psychological Influences on Immune Function and Health. Journal of Consulting and Clinical Psychology, 70(3), 537-547.
Stouffer, M. A., Woods, C. A., Patel, J. C., Lee, C. R. et al. (2015). Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals rewards. Nature Communications, 6, 8543.

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

August 19, 2019

Type 1 Diabetes and the Mind-Body Relationship

The Real Descartes… Believing The Mind, Body And Soul Are In Relationship

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

From Descartes To Integration

I feel I need to start this post with a bit of a get-out clause… I am not a philosopher, nor am I thoroughly grounded in the huge body of works of Descartes. The intention of this post is not to provide a thorough account of the mind-body problem in philosophy. What I intend to do is to highlight how Descartes has influenced Western medicine today. From here, I will be able to focus on my goal for this post… To discuss how I believe that this philosophical position comes to bear on our understanding of Type 1 Diabetes and my ability to heal it.

Who Was Descartes?

By After Frans Hals – André Hatala [e.a.] (1997) De eeuw van Rembrandt, Bruxelles: Crédit communal de Belgique, ISBN 2-908388-32-4., Public Domain, Link

René Descartes (1596–1650) was a mathematician, scientific thinker and philosopher. He is considered to be one of the founders of modern philosophy. Descartes was born in France, where he spent the first 22 years of his life. In 1628, Descartes established himself permanently in the Dutch Republic (now Holland), where he wrote all of his major works. One of his most well-known doctrines concerned the relationship between the mind and the body. He explored this relationship in detail in two of his works: “Principia Philosophiae” [1] and “Meditations” [2].

Mind-Body Dualism

In Principia Philosophiae [1] and in the Second Meditation [3], Descartes outlines his thoughts on the mind-body relationship. Through a series of explorations, Descartes concluded that the mind and body must be made from different substances. He believed that the mind was made from a thinking substance that could not go beyond itself (it could not extend into space). This thinking substance, or “thinking thing”, he called “res cogitans”. The body, by contrast, was understood to be an unthinking substance that was able to extend itself in space. This substance, Descartes named “res extensa” or “extended thing”. Philosophers and theorists alike, since the time of Descartes, have therefore used this line of reasoning to emphasise how Descartes believed that the mind and the body were thus distinct entities. This line of thought is what is referred to today as “Cartesian dualism” or “mind-body dualism”.

The Real Descartes

Descartes [4] is well-known for his phrase “cogito ergo sum” (literally translated as “I think, therefore I am”). It is often used as a symbol to demonstrate how Descartes truly underlined the distinction between the mind and the body.

Such a statement is a debasement and truncation of the intended message of Descartes’ works. Descartes’ writings were, in fact, deeply involved in questioning not only the relationship between the mind and the body but also about the nature of the interactions between them.

A wider reading of Descartes reveals how he believed that the mind, body and soul were in fact not only in relationship with each other but connected via a small region of the brain known as the pineal gland [5, 6]. Descartes [7] posited that the pineal gland was the seat of the soul and the place where all thoughts were formed. Moreover, it was the place where the mind, body and soul interacted. However, throughout his lifetime, Descartes struggled to delineate exactly what the relationships between mind, body and soul were. In letters to friends [8], Descartes was known to devalue and dismiss his metaphysical ideas, aware of their inherent weaknesses and lack of successful theoretical foundation. However, he still maintained that there exists “experience within ourselves certain… things which must not be referred either to the mind alone or to the body alone” but “from the close and intimate union of our mind with the body” [9].

Descartes’ Division Of Mind And Body

As Descartes’ theories of mind, body and soul developed, he encountered trouble. His philosophies offended the Church, who believed that the soul was purely their remit. Thus, in 1663, the Church listed Descartes’ works on its Index of Prohibited books [10]. In order to resolve this growing conflict, Descartes and the Church came to an agreement… The Church would hold sole control over the theorising of the soul, mind and emotions. In return, Descartes would focus solely on the workings of the human body and would be provided with corpses by the Church for purposes of dissection [11]. Thus, the split between mind and body was decided.

Treating Diabetes Using Western Medicine

Mind-body dualism is at the very heart of Western medicine. In doctors’ surgeries, the patient is required to submit their body to be examined, like an object under investigation. Issues in the body are inspected, analysed and assessed. Mental, emotional and spiritual health issues are discussed separately to the physical body and each is treated separately to each other.

Diabetes is understood as a purely bodily, physical medical condition, which needs to be treated with medication [12]. The mental or spiritual elements are generally considered to be outside of the diabetologist’s remit. For me, this became wholly evident when, some years ago, I had a period of suffering from anxiety and depression. At my diabetes check-up, I discussed how my mental health was impacting my ability to maintain tight blood sugar levels. My diabetologist’s response was to refer me to see a psychologist. The diabetologist then continued to work on my blood sugars whilst the psychologist worked on my mind.

Revising Western Medicine’s Theoretical Foundation

Cartesian medicine is coming into question more and more today. With the arrival, and recognition of, psychosomatic illnesses, the line between the mind and the body is becoming increasingly blurred. Some such examples include chronic pain and fibromyalgia. Such conditions are seen as having both mental and physical components that interact with each other. For example, on days with higher pain, mental health can deteriorate. Equally, increased mental health issues, perhaps due to familial or work issues, can result in increased physical pain or decreased flexibility and motility. However, T1D appears to fall outside of that discussion and I question why. Perhaps it is because T1D’s treatment plan relies so heavily on the physical infusions of insulin. I don’t know.

What I do know from my own experience of T1D is that the link between the physical condition and emotions is strong. Personally, I know that my emotions can change quite dramatically when my blood sugars go too low or too high.

Furthermore, according to Diabetes UK [13], three in five diabetics experience emotional or mental health problems as a result of their diabetes. More dramatically still, stressful life events, such as bereavement, divorce and violence, in the family environment during pregnancy and the first two years of life, increase a child’s chance of developing type 1 diabetes [14, 15]. So the link seems to be both ways… The physical condition of diabetes affecting the emotional life of the patient and the emotional life of the patient implicating the onset of the condition in the first place.

So, for me, T1D is not a medical disorder. It is a psychosomatic condition that needs to be seen through the lenses of both mental and physical health.

Going Forward…

If I remove Descartes from my understanding of diabetes, then healing T1D becomes much more multifaceted. My new understanding needs to place treatment on both the mind and the body, preferably in an integrated and holistic way. As such, I will be open to the idea that mind practices can have an effect on my body system, and particularly on the functioning of my pancreas. I will assume that healing T1D involves healing the whole of me. That my immune system can be influenced by my mind. This idea, and practical strategies that I intend to employ, will be outlined and implemented in future posts.

Summary

Descartes’ bastardised philosophies of a disconnection between mind and body are the foundation of Western medicine today.
Cartesian medicine understands physical illnesses and conditions in term of the mechanics of the body, usually conferring that something has gone wrong in the system that is the human body.
Diabetes, as a physical disorder, is understood to result from a misfiring of the immune system. However, no physical cause for this misfiring has been found.
Diabetes can be understood as a multifaceted mind-body disorder, which requires both mental and physical treatment for healing to take place.

References

Descartes, R. (1644). Principia Philosophiae. Amsterdam: Apud Ludovicum Elzevirium. [Link]
Descartes, R. (1658). Meditationes de prima philosophia. Janssonium Juniorum. [Link]
Descartes, R., Sanderson Haldane, E., and Thomson Ross, G. R. (1993). Meditations on First Philosophy in Focus. London and New York: Routledge. (Original work published 1641.) [Link]
Watson, R. (2007). Cogito, ergo sum: The life of Rene Descartes. Boston: David R. Godine. [Link]
Descartes, R. (1972). Treatise on Man (trans. Hall, T. S.). Cambridge, Massachusetts: Harvard University Press. (Original work published 1662.) [Link]
Descartes R. (1989). The Passions of the Soul. Indianapolis: Hackett. (Original work published 1649.) [Link]
Finger, S. (2000). Minds Behind the Brain: A History of the Pioneers and Their Discoveries. New York: Oxford University Press. [Link]
Clarke, D. M. (2006). Descartes: A Biography. Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, Sao Paulo: Cambridge University Press. [Link]
Gottlieb, A. (2016). The Dream of Enlightenment: The Rise of Modern Philosophy. New York and London: Liveright Publishing. [Link]
de Bujanda, J. M. (2002). Index Librorum Prohibitorum, 1600–1966. Montreal and Geneva, Mediaspaul and Librairie Droz. [Link]
Pert, C. B. (1997). Molecules of Emotion: Why You Feel the Way You Feel. London & Sydney: Simon & Schuster. [Link]
https://www.nhs.uk/conditions/diabetes/
https://www.diabetes.org.uk/about_us/news/three-in-five-people-with-diabetes-experience-emotional-or-mental-health-problems
Lundgren, M., Ellstrom, K, and Larsson, H. E. (2018). Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study. Acta Diabetologica, 55(8), 797-804. [Link]
Nygren, M., Carstensen, J., Koch, F., Ludvigsson, J., and Frostell, A. (2015). Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study. Diabetologia, 58(6), 1188-1197. [Link]

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Natalie Leader

Natalie is a blogger with Type 1 Diabetes. Natalie’s special gifts are questioning the status quo and being a rebel. She is using these gifts to question medical ‘knowledge’ and find a true cure for Type 1 Diabetes.

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Recent Comments:

August 5, 2019

The SHOCKING Truth About Insulin!

Hormones, Neuropeptides and… Acid!

The content of the HealingT1D website is for educational and information purposes only. It does not contain medical advice. The contents of this website are not intended to substitute for professional medical advice, diagnosis or treatment. Please always consult with your doctor, physician, or other qualified healthcare professional before making any adjustments to your routine or healthcare regime. HealingT1D and all associated with it will not be held liable for any risks or issues associated with using or acting upon the information on this site.

Summary: This article discusses outlines the role of insulin in diabetes, highlighting how it is a hormone that acts on the permeability of cells. The discovery of insulin by Banting and Best is outlined, followed by a discussion of the modern-day insulins that are available. A consideration of the synthetic components contained within insulin are discussed, along with its properties of being both a hormone and a neuropeptide.

Ah, the elixir! The magic potent drug that keeps me alive and well. What would I do without you?!

Now, for me, it’s funny sitting here writing this post… For decades, I have (mostly!) diligently put insulin into my system. This has been via syringes (originally ones that were sterilised by boiling them in a saucepan!!) then insulin pen devices then an insulin pump and now syringes again. All those units of insulin, all those vials, all those bottles… But I actually know so little about this wonder drug! Is it even a drug?!

What Is Insulin?

So, to answer my first question… No, insulin is not a drug (until it is put into bottles and sold by pharmaceutical giants, anyway!). A plethora of books, articles and webpages kindly inform me that insulin is a hormone [1, 2, 3].

What Are Hormones?

Hormones are a type of molecule in the human body that are transported around the body by the circulatory system. They are taken to places in the body to stimulate specific cells or tissues to produce a predetermined action. The hormone insulin is produced in the pancreas in the beta cells. Insulin is then dispatched into the bloodstream to act on the glucose molecules found there. Insulin works by increasing the permeability of the cells in the human body. With increased permeability, each cell is able to absorb more glucose from the bloodstream, resulting in lower amounts of glucose molecules in the blood [4].

A Brief History Of Insulin

I have to admit that I’m not a great fan of learning about the past. I had a really boring history teacher when I was at school who, I think, successfully put me off history for the rest of my adult life. Saying that, I don’t mind a quick delve into the textbooks of the past when I feel there’s something to be gained. This is true for insulin.

Insulin was not discovered until 1922. Prior to its discovery, the life expectancy of children and young adults with type 1 diabetes was very poor, with deteriorating health and death always imminent. My mother’s great-grandmother was one of the early ones to suffer this fate, dying when she was just 19 years old.

Thankfully, advances have been made. In 1922, insulin was discovered by Frederick Banting and Charles Best, under the directorship of John Macleod, following their investigations into the pancreatic function of dogs [5]. They siphoned off a pancreatic extract from the dogs’ pancreases (what we now know to be insulin) and found that the dogs developed diabetes. By re-injecting this pancreatic extract back into the dogs, the dogs’ blood sugars were lowered.

Charles H. Best and Banting, c. 1924.

The insulin that was extracted from the dogs’ pancreases in these experiments was not purified. Therefore, when it was injected for the first time into a human being, that of a fourteen year old boy, the lack of purification resulted in a sterile abscess and little effect on the blood sugar levels [6]. Banting and Best, with the help of their biochemist colleague J. B. Collip, purified the pancreatic extract, resulting in the first medically viable insulin [7]. In 1923, Banting and Macleod were awarded the Nobel Prize for their discovery of insulin.

Over the following decades, procedures for extracting insulin were refined. Eli Lilly began producing insulin from animal pancreases. He found that the insulin from dead pigs and cows was particularly suited to humans.

In 1982, ‘human’ insulin was produced for the first time. Human insulin is manufactured from genetically engineering the bacterium of yeast cells to produce insulin.

On the market today, there are over 40 different types of insulin available to the diabetic consumer. The vast majority of diabetics use human insulin. However, natural animal insulins, which have no synthetic properties, are still available in some countries, including my home country of the UK. I feel this fact is important to know when considering healing from Type 1 Diabetes. I wish to make my body as healthy as I can, which I believe involves removing as many extraneous toxins as possible.

Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting…

Today, we are blessed to have so many different types of insulin available to us. Whatever our bodily responses to food, exercise and generally just staying alive(!), there is an insulin to match it.

i) Rapid-acting
ii) Short-acting
iii) Intermediate-acting
iv) Long-acting
v) Pre-mixed

Each of these types of insulin have different profiles for how long it takes them to start to work and how long they remain effective in the human body. Rapid-acting insulins, such as Novorapid (also known as Novolog), Humalog and Apidra, all start working in 10-20 minutes and last for two and half hours to five hours (although every human body is different so I only ever take these as rough guides until I’ve seen what they do to me in practice!).

Short-acting insulin tends to have a slower onset and duration than the rapid-acting insulins. Actrapid (also known as Regular insulin) is the most well-known type of insulin in this this group.

NPH is an intermediate-acting insulin, so-called because it takes 1-2 hours to start to work but then last in the system for about half a day.

In the long-acting group is insulin glargine (the most commonly known ones being Lantus and Toujeo), insulin determir (known as Levemir) and Insulin degludec (known as Tresiba). These have a much longer onset time, somewhere between one to two hours depending on the specific type, but last up to 24 hours or longer.

The last group are the pre-mixed insulins, which consist of both short-acting and long-acting insulins.Some examples are Humulin 70/30 and Novolog 70/30, both of which take 30 minutes to onset and last up to 24 hours.

The Lesser Known ‘Amylin’

As I was reading up on insulin production, I found that the insulin-producing beta cells in the pancreas don’t just produce insulin. They also produce another hormone… Amylin.

Amylin is the hormone that helps insulin to attain optimal blood glucose levels after meals. It has many roles…

1. It slows the digestive process, which means that carbohydrates take longer to enter the bloodstream. This results in smaller blood sugar spikes after meals.

2. Prevents glucagon being secreted from the pancreas. Glucagon is a hormone that is responsible for raising blood sugar levels. That means, for me as a type 1 diabetic, I have the added joy of MORE glucagon being released when I eat a meal. So my poor body has to cope with even more free-floating glucose in my bloodstream. Consequently, I have to take more insulin; some to cover the meal itself and some to cover this additional glucagon spike.

3. Amylin increases feelings of satiety. Increasing satiety would dissuade me from reaching for that third second piece of cake after dinner or that lovely chocolate cookie between meals. But, nope, I don’t have amylin. So THAT is why I feel like I… am… always… hungry!!

There is a product on the market called Symlin, which is synthetic amylin that can be used to counteract the lack of amylin in your system.

However, for me, that is not really a choice I wish to make. I am striving to get my body back to as natural a setting as possible and focusing on getting my body to regenerate itself as much as possible. But just knowing that there is a reason why I don’t ever feel satisfied at the end of a meal (no matter how full my belly is!) lets me know that that is okay. I can make peace with that.

My Experience of Insulin

I have been on a range of insulins over the years. When I was first diagnosed, I had two injections a day of mixed Actrapid and Monotard (an old long-acting insulin). This continued until I was eight or nine years old, when I was switched to Novorapid three times per day with meals and Protaphane at bedtime. I have played about with different types since then, including taking purely Novorapid through an insulin pump for a five-year period. Currently, my insulin regime tends to take one of two approaches:

When eating a carbohydrate-rich diet (50-100 grams per day), I find that Novorapid at meal times plus one large-ish dose of Lantus at bedtime is the most effective.

When eating lower amounts of carbohydrates (usually 30-40 grams per day), I require a different regime. I find that Actrapid is more effective for meals (since the protein content of my meals gives the larger blood sugar hit and this hits in later than simple carbohydrates) and two doses of Lantus (at night and in the morning) gives me better stability in my daily blood sugars.

Always Read The Label…

Now this was a bit of a shocker for me. I had always assumed that the insulin I was putting into my body on a more-than-daily basis was just that… Insulin. Well, it turns out that I have been duping myself. I decided to read the package leaflet for each insulin to discover what I was really putting into my body.

Lantus:

At the moment, I use Lantus (insulin glargine) from 3 mL pre-filled cartridges. These contain insulin glargine, plus the following inactive ingredients:

Zinc chloride

Metacresol

Glycerol

Sodium hydroxide

Hydrochloric acid

Water for injections

Category: Taking Control of My Health

Output

Vital Statistics:

Fitness:

Diabetes:

Inflammation:

Kidney Health:

Kidney Health:

Proteins:

Proteins:

Vitamin and Mineral Blood Readings:

Thyroid Functioning:

Improvements in My Output:

My Subjective Assessment of My ‘Output’:

Input:

Medications:

Diabetes:

Vitamin And Mineral Supplements Taken:

My Subjective Assessment Of My ‘Input’:

Recent Comments:

Formatting of this Post

Output:

Vital Statistics:

Fitness:

Diabetes:

Inflammation:

Kidney Health:

Liver Health:

Proteins:

Cholesterol:

Vitamin and Mineral Blood Readings:

Thyroid Functioning:

My Objective Evaluation Of My Bloodwork:

My Subjective Assessment of My ‘Output’:

Input:

Every Day:

My Subjective Assessment Of My ‘Input’:

Recent Comments:

To Tell Or Not To Tell… That Is The Question!

My Reasons For Healing My Type 1 Diabetes

References:

Recent Comments:

Diabetes Resulting From A Lack of Emotional Expression

If Lack of Emotional Expression Has Caused (Or Contributed) To My Type 1 Diabetes, How Do I Reverse It?

Applying The 9 Key Factors to T1D

1. The Healing Factors Did Not Appear To Be Specific To Cancer

2. Only Four of the Factors Directly Involve the Physical Body

My Route Forward….

References:

Recent Comments:

What Is Self-Experimentation?

A Brief History of Self-Experimentation

Self-Experimentation In Diabetes Research

Limitations of Self-Experimentation

Am I Qualified For Self-Experimentation?

References:

Recent Comments:

Hormones

Glucocorticoids:

1. An Ability To Stop Inflammation In The Body:

2. A Role In Regulation Of Glucose Metabolism:

Catecholamines:

What Is Allostasis?

Allostatic Load

How Is Allostatic Load Relevant To T1D?

My Take-Home Message

Summary

After-Thought…

References:

Recent Comments:

References

Recent Comments:

Recent Comments:

Life with T1D

The Finer Detail…

Back To School

The Pancreas

What Are Beta Cells?

Beta Cell Mass and Beta Cell Function

Why Were My Beta Cells Inhibited And/Or Destroyed?